Progress in human liver organoids

查看全文 作　　者：Lulu [1]Sun;Lijian [1,2,3,4]Hui

机构地区：[1]State Key Laboratory of Cell Biology,Chinese Academy of Sciences Center for Excellence in Molecular Cell Science,Shanghai Institute of Biochemistry and Cell Biology,Chinese Academy of Sciences,University of Chinese Academy of Sciences,Shanghai 200031,China;[2]Bio-Research Innovation Center,Shanghai Institute of Biochemistry and Cell Biology,Chinese Academy of Sciences,Suzhou 215121,China;[3]Institute for Stem Cell and Regeneration,Chinese Academy of Sciences,Beijing 100101,China;[4]School of Life Science and Technology,ShanghaiTech University,Shanghai 201210,China

出　　处：《Journal of Molecular Cell Biology》索引2020年第12卷第8期,共11页

基　　金：This study is supported by the Chinese Academy of Sciences(XDA16020201 and XDA12050104);the National Science and Technology Major Project*Key New Drug Creation and Manufacturing Program,(2018ZX09711002-009). 摘　　要：Understanding the development,regeneration,and disorders of the liver is the major goal in liver biology.Current mechanistic knowledge of human livers has been largely derived from mouse models and cell lines,which fall short in recapitulating the features of human liver cells or the structures and functions of human livers.Organoids as an in vitro system hold the promise to generate organ-like tissues in a dish.Recent advances in human liver organoids also facilitate the understanding of the biology and diseases in this complex organ.Here we review the progress in human liver organoids,mainly focusing on the methods to generate liver organoids,their applications,and possible future directions. 关键词：liver organoid PROGRESS PERSPECTIVES

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Progress in human liver organoids

参考文献(94)

引证文献(7)

耦合文献(121)

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