维普中文期刊产品整合服务

Effectiveness and safety of Chinese herbal medicines for hepatitis B virus-related acute-on-chronic liver failure:study protocol for a multicenter randomized controlled trial

查看全文 作　　者：Zhang [1]Ning;Zhou [1]Chao;Wang [1]Lifu;He [1]Tingting;Wang [1]Yao;Wang [1]Yan;Bai [1]Yunfeng;Li [1]Jun;Xiao [1]Xiaohe;Gong [1]Man 高影响力作者 机构地区：[1]Integrated Traditional Chinese Medicine&Western Medicine Department,the Fifth Medical Center,General Hospital of PLA,Beijing 100039,China高影响力机构 出　　处：《Journal of Traditional Chinese Medicine》索引2020年第40卷第6期,共8页高影响力期刊 基　　金：Supported by National Science and Technology Major Project Evaluation of Clinical Efficacy of Chinese Herbal Medicines in Reducing the Mortality of Acute-on-Chronic Liver Failure(No.2018ZX10725-506-002)。 摘　　要：OBJECTIVE:To conduct a multicenter randomized controlled trial of the efficacy of standardized Chinese herbal medicines(CHMs)against acuteon-chronic liver failure(ACLF)and provide reproducible and high-level evidence for clinical practice.METHODS:This is a prospective,multicenter,centrally randomized controlled trial.Patients diagnosed with hepatitis B virus-related ACLF(n=510)will be allocated to the standard medical therapy or CHM group at a 1∶1 ratio.Two CHMs will be used on the basis of the traditional Chinese medicine syndrome:Liangxue Jiedu granules for excess syndromes and Yiqi Jiedu granules for deficiency syndromes.The primary outcome is transplant-free survival at week 12.The secondary outcomes are(a)transplant-free survival at week 24,(b)liver function as assessed using the model for end-stage liver disease score at week 12,(c)liver function as assessed using the Child-Pugh score at week 12,and(d)the incidence of complications at week 12.DISCUSSION:The effectiveness and safety of CHM formulations will be assessed following treatment for ACLF.TRIAL REGISTRATION:The trial was registered at Clinical Trials.gov(NCT03577938)on June 24,2018. 关 键 词：Acute-on-chronic liver failure Hepatitis B CHRONIC DRUGS Chinese herbal Randomized controlled trial Clinical protocols
相关文献

参考文献(25)

引证文献(8)

耦合文献(1029)

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1　渝公网安备 50019002500403号　违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费