Evolution of blood lipids and risk factors of dyslipidemia among people living with human immunodeficiency virus who had received first-line antiretroviral regimens for 3 years in Shenzhen

查看全文 作　　者：Li-Qin [1]Sun;Jia-Ye [2]Liu;Yun [1]He;Yang [1]Zhou;Liu-Mei [1]Xu;Lu-Kun [1]Zhang;Fang [1]Zhao;Xiao-Ning [1]Liu;Ying [1]Song;Ting-Zhi [1]Cao;Yi-Mei [1]Tian;Man [1]Rao;Hui [1]Wang

机构地区：[1]Department of Infectious Diseases,The Third People’s Hospital of Shenzhen,The Second Affiliated Hospital of Southern University of Science and Technology,Shenzhen,Guangdong 518100,China;[2]National Clinical Research Center for Infectious Diseases,The Third People’s Hospital of Shenzhen,The Second Affiliated Hospital of Southern University of Science and Technology,Shenzhen,Guangdong 518100,China

出　　处：《Chinese Medical Journal》索引2020年第23期,共8页

基　　金：This work was supported by the grants from the Sanming Project of Medicine in Shenzhen(Nos.SZSM201612014 and SZSM201512029);Guangdong Basic and Applied Basic Research Foundation(No.2019A1515011197);Science and Technology Innovation Committee of Shenzhen Municipality(No.JCYJ20190809115617365)。 摘　　要：Background:Lipid abnormalities are prevalent among people living with human immunodeficiency virus(HIV)(PLWH)and contribute to increasing risk of cardiovascular events.This study aims to investigate the incidence of dyslipidemia and its risk factors in PLWH after receiving different first-line free antiretroviral regimens.Methods:PLWH who sought care at the Third People’s Hospital of Shenzhen from January 2014 to December 2018 were included,and the baseline characteristics and clinical data during the follow-up were collected,including total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C)and high-density lipoprotein cholesterol(HDL-C).The risk factors of dyslipidemia after antiretroviral therapy were analyzed with the generalized estimating equation model.Results:Among the 7623 PLWH included,the mean levels of TC,HDL-C and LDL-C were 4.23±0.85 mmol/L,1.27±0.29 mmol/L and 2.54±0.65 mmol/L,respectively,and the median TG was 1.17(IQR:0.85-1.68)mmol/L.Compared with that in PLWH receiving tenofovir disoproxil fumarate(TDF)+lamivudine(3TC)+ritonavir-boosted lopinavir(LPV/r),zidovudine(AZT)+3TC+efavirenz(EFV),and AZT+3TC+LPV/r,the incidence of dyslipidemia was lower in PLWH receiving TDF+3TC+EFV.In multivariate analysis,we found that the risks of elevations of TG,TC,and LDL-C were higher with TDF+3TC+LPV/r(TG:odds ratio[OR]=2.82,95%confidence interval[CI]:2.55-3.11,P<0.001;TC:OR=1.24,95%CI:1.14-1.35,P<0.001;LDL:OR=1.06,95%CI:1.00-1.12,P=0.041),AZT+3TC+EFV(TG:OR=1.41,95%CI:1.28-1.55,P<0.001;TC:OR=1.43,95%CI:1.31-1.56,P<0.001;LDL:OR=1.18,95%CI:1.12-1.25,P<0.001),and AZT+3TC+LPV/r(TG:OR=3.08,95%CI:2.65-3.59,P<0.001;TC:OR=2.40,95%CI:1.96-2.94,P<0.001;LDL:OR=1.52,95%CI:1.37-1.69,P<0.001)than with TDF+3TC+EFV,while treatment with TDF+3TC+LPV/r was less likely to restore HDL-C levels compared with TDF+3TC+EFV(OR=0.95,95%CI:0.92-0.97,P<0.001).In addition to antiretroviral regimens,antiretroviral therapy duration,older age,overweight,obesity and other traditional factors were also important risk factors for dyslipidemia.Conclusion:The incidence of dyslipidemia varies with different antiretroviral regimens,with TDF+3TC+EFV having lower risk for dyslipidemia than the other first-line free antiretroviral regimens in China. 关键词：Antiretroviral therapy DYSLIPIDEMIA Metabolic syndrome Non-nucleoside reverse transcriptase inhibitor Nucleoside reverse transcriptase inhibitor Protease inhibitor

相关文献

参考文献（35）
引证文献（17）
耦合文献（12）

参考文献(35)

引证文献(17)

耦合文献(12)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Evolution of blood lipids and risk factors of dyslipidemia among people living with human immunodeficiency virus who had received first-line antiretroviral regimens for 3 years in Shenzhen

参考文献(35)

引证文献(17)

耦合文献(12)

用户提示