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The relationships of vitamin D, vitamin D receptor gene polymorphisms, and vitamin D supplementation with Parkinson's disease

查看全文 作　　者：Lingling [1]Lv;Xuling [1]Tan;Xinke [1]Peng;Rongrong [1]Bai;Qile [1]Xiao;Ting [1]Zou;Jieqiong [2,3,4]Tan;Hainan [1]Zhang;Chunyu [1,5]Wang 高影响力作者 机构地区：[1]Department of Neurology,The Second Xiangya Hospital,Central South University,Changsha 410011,China;[2]Center for Medical Genetics,School of Life Sciences,Central South University,Changsha 410078,China;[3]Hunan Key Laboratory of Animal Models for Human Diseases,Central South University,Changsha 410078,China;[4]Hunan Key Laboratory of Medical Genetics,Central South University,Changsha 410078,China;[5]Department of Medical Genetics,The Second Xiangya Hospital,Central South University,Changsha 410011,China高影响力机构 出　　处：《Translational Neurodegeneration》索引2020年第9卷第3期,共13页高影响力期刊 基　　金：The authors of this review were supported by the National Natural Science Foundation of China(81971201);the National Science Foundation of Hunan Province(2019J40450). 摘　　要：In recent years,many studies have investigated the correlations between Parkinson's disease(PD)and vitamin D status,but the conclusion remains elusive.The present review focuses on the associations between PD and serum vitamin D levels by reviewing studies on the associations of PD with serum vitamin D levels and vitamin D receptor(VDR)gene polymorphisms from PubMed,Web of Science,Cochrane Library,and Embase databases.We found that PD patients have lower vitamin D levels than healthy controls and that the vitamin D concentrations are negatively correlated with PD risk and severity.Furthermore,higher vitamin D concentrations are linked to better cognitive function and mood in PD patients.Findings on the relationship between VDR gene polymorphisms and the risk of PD are inconsistent,but the Fokl(C/M)polymorphism is significantly linked with PD.The occurrence of Fokl(CT)gene polymorphism may influence the risk,severity,and cognitive ability of PD patients,while also possibly influencing the effect of Vitamin D3 supplementation in PD patients.In view of the neuroprotective effects of vitamin D and the close association between vitamin D and dopaminergic neurotransmission,interventional prospective studies on vitamin D supplementation in PD patients should be conducted in the future. 关 键 词：Parkinson's disease Vitamin D VDR gene polymorphisms Vitamin D3 supplementation NEUROPROTECTIVE Dopaminergic neurotransmission
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