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The effect of tensile and fluid shear stress on the in vitro degradation of magnesium alloy for stent applications

查看全文 作　　者：Xue-Nan [1,2]Gu;Yun [1]Lu;Fan [1]Wang;Wenting [1]Lin;Ping [1,2]Li;Yubo [1,2,3]Fan 高影响力作者 机构地区：[1]Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education,School of Biological Science and Medical Engineering,Beihang University,Beijing,10083,China;[2]Beijing Advanced Innovation Centre for Biomedical Engineering,Beihang University,Beijing,102402,China;[3]National Research Center for Rehabilitation Technical Aids,Beijing,100176,China高影响力机构 出　　处：《Bioactive Materials》索引2018年第3卷第4期,共7页高影响力期刊 基　　金：This work was supported by National Natural Science Foundation of China(NSFC,51401007,11472032);A Foundation for the Author of National Excellent Doctoral Dissertation of PR China(201463);Young Elite Scientists Sponsorship Program By CAST(2017QNRC001);The National Key Research and Development Plan(2016YFC1102203,2016YFC1101100,2018YFC1106600). 摘　　要：Magnesium alloys have gained great attention as biodegradable materials for stent applications.Cardiovascular stents are continuously exposed to different types of mechanical loadings simultaneously during service,including tensile,compressive and fluid shear stress.In this study,the in vitro degradation of WE43 wires was investigated under combined effect of tensile loading and fluid shear stress and compared with that experienced an individual loading condition.For the individual mechanical loading treatment,the degradation of magnesium wires was more severely affected by tensile loading than fluid shear stress.Under tensile loading,magnesium wires showed faster increment of corrosion rates,loss of mechanical properties and localized corrosion morphology with the increasing tensile loadings.With the combined stress,smaller variation of the corrosion rates as well as the slower strength degeneration was shown with increasing stress levels,in comparison with the individual treatment of tensile loading.This study could help to understand the effect of complex stress condition on the corrosion of magnesium for the optimization of biodegradable magnesium stents. 关 键 词：Magnesium alloys DEGRADATION STENT STRESS
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