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Bioactive constituents from the leaves of Quercus phillyraeoides A.Gray for-glucosidase inhibitor activity with concurrent antioxidant activity

查看全文 作　　者：Anastasia Wheni [1,2]Indrianingsih;Sanro [3]Tachibana 高影响力作者 机构地区：[1]The United Graduate School of Agricultural Sciences,Ehime University,3-5-7 Tarumi,Matsuyama,Ehime 790-8566,Japan;[2]Research Unit for Development of Chemical Engineering Process,Indonesian Institute of Sciences,Gading,Playen,Gunungkidul,Yogyakarta 55581,Indonesia;[3]Department of Applied Biosciences,Faculty of Agriculture,Ehime University,3-5-7 Tarumi,Matsuyama,Ehime 790-8566,Japan高影响力机构 出　　处：《Food Science and Human Wellness》索引2016年第5卷第2期,共10页高影响力期刊 摘　　要：Severalα-glucosidase inhibitory constituents were isolated from the methanolic extract of the leaves of Quercus phillyraeoides A.Gray(Q.phillyraeoides)using a bioassay-guided fractionation technique.Further separation and purification of the methanol-soluble fraction led to the isolation of constituents with moderate and strong inhibitory activities againstα-glucosidase:α-sitosterol-d-glucoside(1)and condensed tannin fractions(2,3,4,5,and 6).Compound 1 and fractions 2-6 had inhibitory concentration(IC50)values againstm-glucosidase from Saccharomyces cerevisiae of 118.8,2.79,2.78,3.10,2.60,and 3.14μg/mL,respectively,while quercetin as the standard had an IC50 value of 4.80mg/mL.Furthermore,the significant antioxidant activities were evaluated using several assays,such as the DPPH radical scavenging,hydrogen peroxide radical scavenging,reducing power,andβ-carotene-linoleate bleaching assays,and the results suggested that the isolated constituents showed their possible application for treating the hyperglycemia-induced oxidative stress.The results of the present study showed the potential of Q.phillyraeoides as a rich source of natural antidiabetic medicine. 关 键 词：Quercus phillyraeoides A.Gray α-Glucosidase inhibitor Antioxidative activity Lineweaver–Burk plot
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