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Hierarchical dual-porous hydroxyapatite doped dendritic mesoporous silica nanoparticles based scaffolds promote osteogenesis in vitro and in vivo

查看全文 作　　者：Chang [1]Lei;Yuxue [1,2]Cao;Sepanta [2]Hosseinpour;Fang [1]Gao;Jingyu [3]Liu;Jianye [1]Fu;Reuben [2]Staples;Saso [2]Ivanovski;Chun [2]Xu 高影响力作者 机构地区：[1]Australian Institute for Bioengineering and Nanotechnology,The University of Queensland,St.Lucia,QLD,4072,Australia;[2]School of Dentistry,The University of Queensland,Herston,QLD,4006,Australia;[3]School of Chemistry,Physics and Mechanical Engineering,Science and Engineering Faculty,Queensland University of Technology(QUT),Brisbane,QLD,4001,Australia高影响力机构 出　　处：《Nano Research》索引2021年第14卷第3期,共8页高影响力期刊 基　　金：the support from University of Queensland (UQ) Early Career Researcher Grant (No.1717673). 摘　　要：Biomaterial based scaffolds for treating large bone defects require excellent biocompatibility and osteoconductivity.Here we report on the fabrication of hydroxyapatite-dendritic mesoporous silica nanoparticles(HA-DMSN)based scaffolds with hierarchical micro-pores(5µm)and nano-pores(6.4 nm),and their application for bone regeneration.The in vitro studies demonstrated good biocompatibility of dissolution extracts,as well as enhanced osteogenic potential indicated by dose-dependent upregulation of bone marker gene expression(osteocalcin gene(OCN),osteopontin gene(OPN),collagen type I alpha 1 gene(CoL1A1),runt-related transcription factor 2 gene(RUNX2),and integrin-binding sialoprotein gene(IBSP)),alkaline phosphatise(ALP)activity,and alizarin red staining.The in vivo studies showed that HA-DMSN scaffolds significantly increased bone formation in a rat cranial bone defect model after 4 weeks healing.Our study provides a simple method to fabricate promising inorganic scaffolds with hierarchical pores for bone tissue engineering. 关 键 词：tissue engineering scaffolds HYDROXYAPATITE dendritic mesoporous silica nanoparticles
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