Liquid-liquid phase separation by SARS-CoV-2 nucleocapsid protein and RNA

查看全文 作　　者：Hui [1,2]Chen;Yang [2]Cui;Xuling [2,3]Han;Wei [4,5]Hu;Min [2]Sun;Yong [2]Zhang;Pei-Hui [6]Wang;Guangtao [2]Song;Wei [4,5]Chen;Jizhong [2,3,7]Lou

机构地区：[1]Shenzhen,Guangdong 518102,China;[2]Key Laboratory of RNA Biology,CAS Center for Excellence in Biomacromolecules,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China;[3]University of Chinese Academy of Sciences,Bejing 100084,China;[4]Department of Cell Biology and Department of Cardiology of the Second Affliated Hospital,Zhejiang,University School of Medicine,Hangzhou,Zhejiang 310058,China;[5]SKey Laboratory for Biomedical Engineering of Ministry of Education,State Key Laboratory for Modern Optical Instrumentation,and Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases,Zhejiang University,Hangzhou,Zhejiang 310058,China;[6]Advanced Medical Research institute,Cheeloo College of Medicine,Shandong University,Jinan,Shandong 250012,China;[7]Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory),Guangzhou,Guangdong 510320,China

出　　处：《Cell Research》索引2020年第30卷第12期,共3页

基　　金：by grants from the Ministry of Science and Technology of China(2019YFA0707001 to J.L.,2017ZX10203205 to W.C.);the National Natural Science Foundation of China(11672317 to J.L.,31971237 to W.C.);Zhejiang University special scientific research fund for COVID-19 prevention and control(2020XGZX077 to W.C.);the COVID-19 emergency tackling research project of Shandong University(2020XGB03 to P.-H.W.). 摘　　要：Dear Editor,The COVID-19 pandemic worldwide is caused by a novel coronavirus SARS-CoV-2(the severe acute respiratory syndrome coronavirus 2).1 After viral invasion into the host cells,the〜30 kb viral genome RNA injected is translated into structural and nonstructural proteins to replicate viral genome and assemble more viral particles.Many copies of nucleocapsid(N)protein can bind to viral genome RNA and pack it into^100 nm particles,assisting membrane(M)and envelope(E)proteins to efficiently assemble the viral envelope.2 The exact molecular mechanism by which N protein packs up the viral genome still remains elusive. 关键词：INVASION ACUTE RESPIRATORY

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Liquid-liquid phase separation by SARS-CoV-2 nucleocapsid protein and RNA

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