Systemic adverse effects and toxicities associated with immunotherapy:A review

查看全文 作　　者：Asim [1,2]Kichloo;Michael [3]Albosta;Dushyant [1]Dahiya;Jean Claude [2]Guidi;Michael [1]Aljadah;Jagmeet [4]Singh;Hafeez [5]Shaka;Farah [6]Wani;Akshay [7]Kumar;Manidhar [8]Lekkala

机构地区：[1]Department of Internal Medicine,Central Michigan University,Saginaw,MI 48603,United States;[2]Department of Internal Medicine,Samaritan Medical Center,Watertown,NY 13601,United States;[3]Department of Internal Medicine,Medical College of Wisconsin,Milwaukee,WI 53201,United States;[4]Department of Nephrology,Guthrie Robert Packer Hospital,Sayre,PA 18840,United States;[5]Department of Internal Medicine,John H Stroger Jr.Hospital of Cook County,Chicago,IL 60612,United States;[6]Department of Family Medicine,Samaritan Medical Center,Watertown,NY 13601,United States;[7]Department of Surgery,University of Pittsburgh,Pittsburgh,PA 15213,United States;[8]Department of Hematology and Oncology,University of Rochester Medical Center,Rochester,NY 14642,United States

出　　处：《World Journal of Clinical Oncology》索引2021年第12卷第3期,共14页

摘　　要：Immunotherapy is rapidly evolving secondary to the advent of newer immunotherapeutic agents and increasing approval of the current agents by the United States Food and Drug Administration to treat a wide spectrum of cancers.Immunotherapeutic agents have gained immense popularity due to their tumorspecific action.Immunotherapy is slowly transforming into a separate therapeutic entity,and the fifth pillar of management for cancers alongside surgery,radiotherapy,chemotherapy,and targeted therapy.However,like any therapeutic entity it has its own adverse effects.With the increasing use of immunotherapeutic agents,it is vital for physicians to acquaint themselves with these adverse effects.The aim of this review is to investigate the common systemic adverse effects and toxicities associated with the use of different classes of immunotherapeutic agents.We provide an overview of potential adverse effects and toxicities associated with different classes of immunotherapeutic agents organized by organ systems,as well as an extensive discussion of the current recommendations for treatment and clinical trial data.As we continue to see increasing usage of these agents in clinical practice,it is vital for physicians to familiarize themselves with these effects. 关键词：IMMUNOTHERAPY Cancer MALIGNANCY Adverse effects Immune checkpoint inhibitor Monoclonal antibody

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Systemic adverse effects and toxicities associated with immunotherapy:A review

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