维普中文期刊产品整合服务

Hepatitis E in solid organ transplant recipients:A systematic review and meta-analysis

查看全文 作　　者：Panupong [1]Hansrivijit;Angkawipa [2]Trongtorsak;Max M [3]Puthenpura;Boonphiphop [4]Boonpheng;Charat [5]Thongprayoon;Karn [6]Wijarnpreecha;Avishek [7]Choudhury;Wisit [8]Kaewput;Shennen A [9]Mao;Michael A [10]Mao;Caroline C [11]Jadlowiec;Wisit [12]Cheungpasitporn 高影响力作者 机构地区：[1]Department of Internal Medicine,UPMC Pinnacle,Harrisburg,PA 17104,United States;[2]Department of Internal Medicine,Amita Health Saint Francis Hospital,Evanston,IL 60202,United States;[3]Department of Medicine,Drexel University College of Medicine,Philadelphia,PA 19129,United States;[4]David Geffen School of Medicine,University of California,Los Angeles,Division of Nephrology,Los Angeles,CA 90095,United States;[5]Department of Internal Medicine,Mayo Clinic,Rochester,MN 55905,United States;[6]Department of Gastroenterology and Hepatology,Mayo Clinic College of Medicine,Jacksonville,FL 32224,United States;[7]School of Systems and Enterprises,Stevens Institute of Technology,Hoboken,NJ 07030,United States;[8]Department of Military and Community Medicine,Phramongkutklao College of Medicine,Bangkok 10400,Thailand;[9]Department of Transplant Surgery,Mayo Clinic,Jacksonville,FL 32224,United States;[10]Department of Nephrology and Hypertension,Mayo Clinic,Jacksonville,FL 32224,United States;[11]Department of Transplant Center,Mayo Clinic,Scottsdale,AZ 85259,United States;[12]Department of Medicine,Mayo Clinic,Rochester,MN 55905,United States高影响力机构 出　　处：《World Journal of Gastroenterology》索引2021年第27卷第12期,共15页高影响力期刊 摘　　要：BACKGROUND Hepatitis E virus(HEV)infection is underdiagnosed due to the use of serological assays with low sensitivity.Although most patients with HEV recover completely,HEV infection among patients with pre-existing chronic liver disease and organ-transplant recipients on immunosuppressive therapy can result in decompensated liver disease and death.AIM To demonstrate the prevalence of HEV infection in solid organ transplant(SOT)recipients.METHODS We searched Ovid MEDLINE,EMBASE,and the Cochrane Library for eligible articles through October 2020.The inclusion criteria consisted of adult patients with history of SOT.HEV infection is confirmed by either HEV-immunoglobulin G,HEV-immunoglobulin M,or HEV RNA assay.RESULTS Of 563 citations,a total of 22 studies(n=4557)were included in this metaanalysis.The pooled estimated prevalence of HEV infection in SOT patients was 20.2%[95%confidence interval(CI):14.9-26.8].The pooled estimated prevalence of HEV infection for each organ transplant was as follows:liver(27.2%;95%CI:20.0-35.8),kidney(12.8%;95%CI:9.3-17.3),heart(12.8%;95%CI:9.3-17.3),and lung(5.6%;95%CI:1.6-17.9).Comparison across organ transplants demonstrated statistical significance(Q=16.721,P=0.002).The subgroup analyses showed that the prevalence of HEV infection among SOT recipients was significantly higher in middle-income countries compared to high-income countries.The pooled estimated prevalence of de novo HEV infection was 5.1%(95%CI:2.6-9.6)and the pooled estimated prevalence of acute HEV infection was 4.3%(95%CI:1.9-9.4).CONCLUSION HEV infection is common in SOT recipients,particularly in middle-income countries.The prevalence of HEV infection in lung transplant recipients is considerably less common than other organ transplants.More studies examining the clinical impacts of HEV infection in SOT recipients,such as graft failure,rejection,and mortality are warranted. 关 键 词：Hepatitis E virus Hepatitis E virus infection Solid organ transplant PREVALENCE
相关文献

参考文献(47)

引证文献(3)

耦合文献(2)

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1　渝公网安备 50019002500403号　违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费