Internal connections between dietary intake and gut microbiota homeostasis in disease progression of ulcerative colitis:a review

查看全文 作　　者：Wen [1]Zeng;Dong [1]He;Yifan [1]Xing;Junyu [1]Liu;Nan [1]Su;Chong [1,2]Zhang;Yi [1]Wang;Xinhui [1,2,3]Xing

机构地区：[1]MOE Key Laboratory for Industrial Biocatalysis,Institute of Biochemical Engineering,Department of Chemical Engineering,Tsinghua University,Beijing 100084,China;[2]Centre for Synthetic and Systems Biology,Tsinghua University,Beijing 100084,China;[3]Institute of Biopharmaceutical and Health Engineering,Tsinghua Shenzhen International Graduate School,Shenzhen 518055,China

出　　处：《Food Science and Human Wellness》索引2021年第10卷第2期,共12页

基　　金：the National Key Research and Development Plan,China(2016YFD0400203-4). 摘　　要：Ulcerative colitis(UC)is a chronic systematic inflammation disorder with increasing incidence,unknown pathogenesis,limited drug treatment,and abundant medical expenses.Dietary intake,as a daily indispensable environment factor,is closely related to UC pathogenesis and prevention.The underlying interactions between dietary intake and UC progression are implicated with the modulation of gut microbiome as well as microbial metabolites,suggesting the complex and systematic characteristics of UC.However,the triangular relationships with dietary intake,gut microbiota homeostasis,and UC have not been well summarized so far.Here we review the recent studies of dietary intake on the regulation of gut microbiome homeostasis as well as modulation of UC progression.These findings suggest that varieties in dietary patterns result in the production of diverse microbial fermentation metabolites,which contribute to gut microbiome homeostasis through multiple manipulations including immune modulation,inftammation restriction as well as epithelial barrier maintenance,thus finally determine the fate of UC progression and give implications for functional food development for prevention and treatment of UC patients. 关键词：Ulcerative colitis Dietary intake Gut microbiome METABOLITE HOMEOSTASIS

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Internal connections between dietary intake and gut microbiota homeostasis in disease progression of ulcerative colitis:a review

参考文献(162)

引证文献(8)

耦合文献(288)

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