The intrinsic axon regenerative properties of mature neurons after injury

查看全文 作　　者：Chunfeng [1]Liu;Jinlian [1]Liu;Chaoqun [1]Liu;Qing [1]Zhou;Yaodong [1]Zhou;Boyin [2]Zhang;[3]Saijilafu

机构地区：[1]Department of Orthopedic Surgery,Suzhou Kowloon Hospital,Shanghai Jiaotong University Medical School,Suzhou 215000,China;[2]Orthopedics Surgery Department,China-Japan Union Hospital of Jilin University,Changchun 130033,China;[3]Department of Orthopaedics,The First Affiliated Hospital,Orthopaedic Institute,Soochow University,Suzhou 215007,China

出　　处：《Acta Biochimica et Biophysica Sinica》索引2021年第53卷第1期,共9页

基　　金：This work was supported by the grants from the National Key Research and Development Program(No.2016YFC 1100203);the National Natural Science Foundation of China(No.81772353);the Priority Academic Program Development of Jiangsu Higher Education Institutions,and Innovation and Entrepreneurship Program of Jiangsu Province to S.,and the Grants from National Natural Science Foundation of China(No.81701225);the Research Grant of Department of Education of Jilin Province of China(No.JJKH 20201056K J);the Research Grant of Science and Technology Department of Jilin Province of China(Nos.20190103077JH and 20200201436JC)to B.Z. 摘　　要：Thousands of nerve injuries occur in the world each year.Axon regeneration is a very critical process for the restoration of the injured nervous system’s function.However,the precise molecular mechanism or signaling cascades that control axon regeneration are not clearly understood,especially in mammals.Therefore,there is almost no ideal treatment method to repair the nervous system’s injury until now.Mammalian axonal regeneration requires multiple signaling pathways to coordinately regulate gene expression in soma and assembly of the cytoskeleton protein in the growth cone.A better understanding of their molecular mechanisms,such as axon regeneration regulatory signaling cascades,will be helpful in developing new treatment strategies for promoting axon regeneration.In this review,we mainly focus on describing these regeneration-associated signaling cascades,which regulate axon regeneration. 关键词：axon regeneration signaling pathway growth cone SOMA

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The intrinsic axon regenerative properties of mature neurons after injury

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