Immunopathobiology and therapeutic targets related to cytokines in liver diseases

查看全文 作　　者：Yong [1]He;Seonghwan [1]Hwang;Yeni Ait [1,2]Ahmed;Dechun [1]Feng;Na [3]Li;Marcelle [4]Ribeiro;Fouad [2,5,6]Lafdil;Tatiana [3]Kisseleva;Gyongyi [4]Szabo;Bin [1]Gao

机构地区：[1]Laboratory of Liver Diseases,National Institute on Alcohol Abuse and Alcoholism,National Institutes of Health,Bethesda,MD 20892,USA;[2]Universite Paris-Est,UMR-S955,UPEC,F-94000 Creteil,France;[3]Department of Medicine and Department of Surgery,School of Medicine,University of California,San Diego,CA 92093,USA;[4]Department of Medicine,Beth Israel Deaconess Medical Center and Harvard Medical School,Boston,MA,USA;[5]INSERM,U955,F-94000 Creteil,France;[6]Institut Universitaire de France(IUF),Paris F-75231 Cedex 05,France

出　　处：《Cellular & Molecular Immunology》索引2021年第18卷第1期,共20页

基　　金：supported by the intramural program of the NIAAA(Bin Gao),U01 AA022614,and R01 DK099205(Tatiana Kisseleva)and AA011576 and AA017729(Gyongyi Szabo). 摘　　要：Chronic liver injury with any etiology can progress to fibrosis and the end-stage diseases cirrhosis and hepatocellular carcinoma.The progression of liver disease is controlled by a variety of factors,including liver injury,inflammatory cells,inflammatory mediators,cytokines,and the gut microbiome.In the current review,we discuss recent data on a large number of cytokines that play important roles in regulating liver injury,inflammation,fibrosis,and regeneration,with a focus on interferons and T helper(Th)1,Th2,Th9,Th17,interleukin(IL)-1 family,IL-6 family,and IL-20 family cytokines.Hepatocytes can also produce certain cytokines(such as IL-7,IL-11;and IL-33),and the functions of these cytokines in the liver are briefly summarized.Several cytokines have great therapeutic potential,and some are currently being tested as therapeutic targets in clinical trials for the treatment of liver diseases,which are also described. 关键词：T helper ALD NAFLD FIBROSIS INFLAMMATION

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Immunopathobiology and therapeutic targets related to cytokines in liver diseases

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