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Growing vertical aligned mesoporous silica thin film on nanoporous substrate for enhanced degradation,drug delivery and bioactivity

查看全文 作　　者：Zhe [1]Li;Yide [1]He;Lasse Hyldgaard [2]Klausen;Ning [1]Yan;Jing [1]Liu;Fanghao [1]Chen;Wen [1]Song;Mingdong [2]Dong;Yumei [1]Zhang 高影响力作者 机构地区：[1]State Key Laboratory of Military Stomatology&National Clinical Research Center for Oral Diseases&Shaanxi Key Laboratory of Oral Diseases,Department of Prosthodontics,School of Stomatology,The Fourth Military Medical University,Xi’an,710032,China;[2]Interdisciplinary Nanoscience Center(iNANO),Aarhus University,Aarhus,8000,Denmark高影响力机构 出　　处：《Bioactive Materials》索引2021年第6卷第5期,共12页高影响力期刊 基　　金：the National Natural Science Foundation of China[grant numbers 81530051,31800790 and 31670966];Shaanxi Provincial Key Research and Development Plan Project(2019SF-031);Young Talent fund of University Association for Science and Technology in Shaanxi,China(20190304);supported by Danmarks Frie Forskningsfond(9040-00219B);Carlsbergfondet。 摘　　要：Mesoporous silica thin film has been widely used in various fields,particularly the medical implant coating for drug delivery.However,some drawbacks remain with the films produced by traditional method(evaporation-induced self-assembly,EISA),such as the poor permeability caused by their horizontal aligned mesochannels.In this study,the vertical aligned mesoporous silica thin film(VMSTF)is uniformly grown alongside the walls of titania nanotubes array via a biphase stratification growth method,resulting in a hierarchical two-layered nanotubular structure.Due to the exposure of opened mesopores,VMSTF exhibits more appealing performances,including rapid degradation,efficient small-molecular drug(dexamethasone)loading and release,enhanced early adhesion and osteogenic differentiation of MC3T3-E1 cells.This is the first time successfully depositing VMSTF on nanoporous substrate and our findings suggest that the VMSTF may be a promising candidate for bone implant surface coating to obtain bioactive performances. 关 键 词：Mesoporous silica film Vertical aligned mesochannels Titania nanotubes array Drug delivery OSTEOBLASTS
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