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Accelerating ESD-induced gastric ulcer healing using a pH-responsive polyurethane/small intestinal submucosa hydrogel delivered by endoscopic catheter

查看全文 作　　者：Long-Mei [1]Zhao;Mei [1]Gong;Rui [1]Wang;Qi-Juan [1]Yuan;Yi [1]Zhang;Jin-Kui [2]Pi;Xiu-He [3]Lv;Yan [3]Xie;Hui-Qi [1]Xie 高影响力作者 机构地区：[1]Laboratory of Stem Cell and Tissue Engineering,Orthopedic Research Institute,State Key Laboratory of Biotherapy and Cancer Center,West China Hospital,Sichuan University and Collaborative Innovation Center of Biotherapy,Keyuan Road 4,Gaopeng Street Chengdu,Sichuan 610041,China;[2]Research Core Facility,West China Hospital,Sichuan University,Keyuan Road 4,Gaopeng Street,Chengdu,Sichuan 610041,China;[3]Department of Gastroenterology,West China Hospital,Sichuan University,No.37 Guo Xue Xiang,Chengdu,Sichuan 610041,China高影响力机构 出　　处：《Regenerative Biomaterials》索引2021年第8卷第1期,共12页高影响力期刊 基　　金：This work was supported by The National Key R&D Program of China(2017YFC1104702);Sichuan Science and Technology Program(2019JDRC0020);the 1.3.5 Project for Disciplines of Excellence,West China Hospital,Sichuan University(ZYJC18002). 摘　　要：Endoscopic submucosal dissection(ESD)is the standard treatment for early-stage gastric cancer,but the large post-operative ulcers caused by ESD often lead to serious side effects.Post-ESD mu-cosal repair materials provide a new option for the treatment of post-ESD ulcers.In this study,we developed a polyurethane/small intestinal submucosa(PU/SIS)hydrogel and investigated its effi-cacy for accelerating ESD-induced ulcer healing in a canine model.PU/SIS hydrogel possessed great biocompatibility and distinctive pH-sensitive swelling properties and protected GES-1 cells from acid attack through forming a dense film in acidic conditions in vitro.Besides,PU/SIS gels present a strong bio-adhesion to gastric tissues under acidic conditions,thus ensuring the reten-tion time of PU/SIS gels in vivo.In a canine model,PU/SIS hydrogel was easily delivered via endoscopy and adhered to the ulcer sites.PU/SIS hydrogel accelerated gastric ulcer healing at an early stage with more epithelium regeneration and slight inflammation.Our findings reveal PU/SIS hydrogel is a promising and attractive candidate for ESD-induced ulcer repair. 关 键 词：ESD-induced ulc er small inte stinal submucosa POLYURETHANE bio-a dhesion PH-SENSITIVE
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