维普中文期刊产品整合服务

Biodegradable Zn-Sr alloy for bone regeneration in rat femoral condyle defect model: In vitro and in vivo studies

查看全文 作　　者：Bo [1,3]Jia;Hongtao [2,4]Yang;Zechuan [2]Zhang;Xinhua [5]Qu;Xiufeng [6]Jia;Qiang [1]Wu;Yu [1]Han;Yufeng [2]Zheng;Kerong [1]Dai 高影响力作者 机构地区：[1]Department of Orthopaedic Surgery,Shanghai Key Laboratory of Orthopaedic Implants,Shanghai Ninth People’s Hospital,Shanghai Jiaotong University,School of Medicine,Shanghai,200011,China;[2]Department of Materials Science and Engineering,College of Engineering,Peking University,Beijing,100871,China;[3]Department of Orthopedics,Shanghai General Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai,200080,China;[4]Department of Materials Science and Engineering,The Ohio State University,Columbus,OH,43210,United States;[5]Department of Bone and Joint Surgery,Renji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai,200127,China;[6]Department of Orthopaedic Surgery,Wudi People’s Hospital,Binzhou,251900,China高影响力机构 出　　处：《Bioactive Materials》索引2021年第6卷第6期,共17页高影响力期刊 基　　金：This work was supported by the National Natural Science Foundation of China[Grant No.51931001]. 摘　　要：Bone defects are commonly caused by severe trauma,malignant tumors,or congenital diseases and remain among the toughest clinical problems faced by orthopedic surgeons,especially when of critical size.Biodegradable zinc-based metals have recently gained popularity for their desirable biocompatibility,suitable degradation rate,and favorable osteogenesis-promoting properties.The biphasic activity of Sr promotes osteogenesis and inhibits osteoclastogenesis,which imparts Zn-Sr alloys with the ideal theoretical osteogenic properties.Herein,a biodegradable Zn-Sr binary alloy system was fabricated.The cytocompatibility and osteogenesis of the Zn-Sr alloys were significantly better than those of pure Zn in MC3T3-E1 cells.RNA-sequencing illustrated that the Zn-0.8Sr alloy promoted osteogenesis by activating the wnt/β-catenin,PI3K/Akt,and MAPK/Erk signaling pathways.Furthermore,rat femoral condyle defects were repaired using Zn-0.8Sr alloy scaffolds,with pure Ti as a control.The scaffold-bone integration and bone ingrowth confirmed the favorable in vivo repair properties of the Zn-Sr alloy,which was verified to offer satisfactory biosafety based on the hematoxylin-eosin(H&E)staining and ion concentration testing of important organs.The Zn-0.8Sr alloy was identified as an ideal bone repair material candidate,especially for application in critical-sized defects on load-bearing sites due to its favorable biocompatibility and osteogenic properties in vitro and in vivo. 关 键 词：Biodegradable metal Zn–Sr alloy Bone defects Bone repair material OSTEOGENESIS
相关文献

参考文献(70)

引证文献(27)

耦合文献(36)

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1　渝公网安备 50019002500403号　违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费