Development of stem cell-based therapy for Parkinson’s disease

查看全文 作　　者：Fabin [1]Han;Deborah [1]Baremberg;Junyu [1]Gao;Jing [1]Duan;Xianjie [1]Lu;Nan [1]Zhang;Qingfa [1]Chen

机构地区：[1]Centre for Stem Cells and Regenerative Medicine,The Liaocheng People’s Hospital/Affiliated Liaocheng Hospital,Taishan Medical University,Shandong 252000,China

出　　处：《Translational Neurodegeneration》索引2015年第4卷第1期,共13页

基　　金：by National Natural Science Foundation of China(NSFC 81271251);The Science and Technology Developmental Fund of Shandong Province,China(2012GGA15049). 摘　　要：Parkinson’s disease(PD)is one of the most common neurodegenerative disorders of aging,characterized by the degeneration of dopamine neurons(DA neurons)in the substantial nigra,leading to the advent of both motor symptoms and non-motor symptoms.Current treatments include electrical stimulation of the affected brain areas and dopamine replacement therapy.Even though both categories are effective in treating PD patients,the disease progression cannot be stopped.The research advance into cell therapies provides exciting potential for the treatment of PD.Current cell sources include neural stem cells(NSCs)from fetal brain tissues,human embryonic stem cells(hESCs),induced pluripotent stem cells(iPSCs)and directly induced dopamine neurons(iDA neurons).Here,we evaluate the research progress in different cell sources with a focus on using iPSCs as a valuable source and propose key challenges for developing cells suitable for large-scale clinical applications in the treatment of PD. 关键词：Parkinson’s disease Dopamine neuron Neural stem cell Human embryonic stem cells Induced pluripotent stem cell Induced dopamine neuron

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Development of stem cell-based therapy for Parkinson’s disease

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