No association between Parkinson disease and autoantibodies against NMDA-type glutamate receptors

查看全文 作　　者：Franziska [1,27]Hopfner;Stefanie [1]HMüller;Dagmar [2]Steppat;Joanna [2]Miller;Nele [1]Schmidt;Klaus-Peter [3]Wandinger;Frank [1,3]Leypoldt;Daniela [1,14,15]Berg;Andre [4]Franke;Wolfgang [5]Lieb;Lukas [5]Tittmann;Monika Balzer-[6,7]Geldsetzer;Simon [8,9]Baudrexel;Richard [6,7]Dodel;Ruediger Hilker-[8,9]Roggendorf;Elke [10,11]Kalbe;Jan [12]Kassubek;Thomas [13]Klockgether;Inga Liepelt-[14,15]Scarfone;Brit [16,17]Mollenhauer;Petra [18]Neuser;Kathrin [19,20]Reetz;Oliver [21]Riedel;Claudia [14,15]Schulte;Jörg [19,20]BSchulz;Annika [13]Spottke;Alexander [22,23,24]Storch;Claudia [16,17]Trenkwalder;Hans-Ulrich [25,26,27]Wittchen;Karsten [1,28,29]Witt;Ullrich [13]Wüllner;Günther [1]Deuschl;Gregor [1]Kuhlenbäumer

机构地区：[1]Department of Neurology,University Hospital Schleswig Holstein,Arnold-Heller Str.3,24105 Kiel,Germany;[2]Center of Blood Transfusion,University Hospital Schleswig Holstein,Kiel&Lübeck,Germany;[3]Department of Clinical Chemistry,University Hospital Schleswig-Holstein,Kiel,Germany;[4]Institute of Clinical Molecular Biology,University Hospital Schleswig-Holstein,Kiel,Germany;[5]Institute of Epidemiology,University Hospital Schleswig-Holstein,Kiel,Germany;[6]Chair of Geriatric Medicine,University Hospital Essen,Essen,Germany;[7]Department of Neurology,Philipps-University Marburg,Marburg,Germany;[8]Department of Neurology,Goethe University,Frankfurt/Main,Germany;[9]Brain Imaging Center,Goethe University,Frankfurt/Main,Germany;[10]Department of Medical Psychology|Neuropsychology and Gender Studies&Center for Neuropsychological Diagnostics and Intervention(CeNDI),University Hospital Cologne,Cologne,Germany;[11]Psychological Gerontology,Institute of Gerontology,University of Vechta,Vechta,Germany;[12]Department of Neurology,University of Ulm,Ulm,Germany;[13]Department of Neurology,University of Bonn,and German Center for Neurodegenerative Diseases(DZNE),Bonn,Germany;[14]Center for Neurology,Hertie Institute for Clinical Brain Research,Department of Neurodegenerative Diseases,University of Tübingen,Tübingen,Germany;[15]DZNE,German Center for Neurodegenerative Diseases,Tübingen,Germany;[16]Paracelsus-Elena-Klinik,Kassel,Germany;[17]Institute of Neuropathology and Department of Neurosurgery,University Medical Center Göttingen,Göttingen,Germany;[18]Coordinating Centre for Clinical Trials,Philipps-University,Marburg,Germany;[19]Department of Neurology,RWTH Aachen University,Aachen,Germany;[20]JARA-BRAIN Institute of Molecular Neuroscience and Neuroimaging,Forschungszentrum Jülich GmbH and RWTH Aachen University,Aachen,Germany;[21]Leibniz Institute for Prevention Research and Epidemiology-BIPS,Achterstrasse 30,28359 Bremen,Germany;[22]Department of Neurology,Technische Universität Dresden,01307 Dresden,Germany;[23]German Center for Neurodegenerative Diseases(DZNE),Research Site Rostock,18147 Rostock,Germany;[24]Department of Neurology,University of Rostock,18147 Rostock,Germany;[25]Technische Universtität Dresden,Institute of Clinical Psychology and Psychotherapy,Chemnitzer Str.46,01187 Dresden,Germany;[26]Technische Universtität Dresden,Center for Epidemiological and Longitudinal Studies(CELOS),Chemnitzer Str.46,01187 Dresden,Germany;[27]Department of Psychiatry and Psychotherapy,Ludwig-Maximilians-Universität München,Nußbaumstraße 7,80336 München,Germany;[28]Department of Neurology,European Medical School,University Oldenburg,Oldenburg,Germany;[29]Research Center Neurosensory Science,Carl von Ossietzky University Oldenburg,Oldenburg,Germany

出　　处：《Translational Neurodegeneration》索引2019年第8卷第1期,共7页

基　　金：Intramural funding of the Dept.of Neurology,Kiel University. 摘　　要：Background:IgG-class autoantibodies to N-Methyl-D-Aspartate(NMDA)-type glutamate receptors define a novel entity of autoimmune encephalitis.Studies examining the prevalence of NMDA IgA/IgM antibodies in patients with Parkinson disease with/without dementia produced conflicting results.We measured NMDA antibodies in a large,well phenotyped sample of Parkinson patients without and with cognitive impairment(n=296)and controls(n=295)free of neuropsychiatric disease.Detailed phenotyping and large numbers allowed statistically meaningful correlation of antibody status with diagnostic subgroups as well as quantitative indicators of disease severity and cognitive impairment.Methods:NMDA antibodies were analysed in the serum of patients and controls using well established validated assays.We used anti-NMDA antibody positivity as the main independent variable and correlated it with disease status and phenotypic characteristics.Results:The frequency of NMDA IgA/IgM antibodies was lower in Parkinson patients(13%)than in controls(22%)and higher than in previous studies in both groups.NMDA IgA/IgM antibodies were neither significantly associated with diagnostic subclasses of Parkinson disease according to cognitive impairment,nor with quantitative indicators of disease severity and cognitive impairment.A positive NMDA antibody status was positively correlated with age in controls but not in Parkinson patients.Conclusion:It is unlikely albeit not impossible that NMDA antibodies play a significant role in the pathogenesis or progression of Parkinson disease e.g.to Parkinson disease with dementia,while NMDA IgG antibodies define a separate disease of its own. 关键词：NMDA antibody NMDA IgA/IgM antibodies Parkinson disease Cognitive impairment

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No association between Parkinson disease and autoantibodies against NMDA-type glutamate receptors

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