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Marginal zone B cells are naturally reactive to collagen type II and are involved in the initiation of the immune response in collagen-induced arthritis

查看全文 作　　者：Cecilia [1]Carnrot;Kajsa E [1,2]Prokopec;Kristina [1]Rasbo;Mikael CI [2]Karlsson;Sandra [1]Kleinau 高影响力作者 机构地区：[1]Department of Cell and Molecular Biology,Uppsala University,Uppsala,Sweden;[2]Department of Medicine,Unit of Clinical Allergy Research,The Karolinska Institute,Solna,Sweden高影响力机构 出　　处：《Cellular & Molecular Immunology》索引2011年第8卷第4期,共9页高影响力期刊 基　　金：This research project was supported by the Swedish Research Council and The King Gustav V’s 80 years Foundation 摘　　要：Antibodies against type II collagen(CII)are essential for development of collagen-induced arthritis(CIA),but how and where the B-cell response to CII is initiated is not fully known.We show here that naive DBA/1 mice display naturally reactive IgM and IgG anti-CII producing B cells prior to immunization.The CII-reactive B cells were observed in the spleen and recognized as marginal zone(MZ)B cells.After CII immunization,CII-specific B cells expanded rapidly in the spleen,in contrast to the lymph nodes,with the initial response derived from MZ B cells and later by follicular(FO)B cells.This was evident despite that the MZ B cells were subject to stringent tolerance mechanisms by having a greater Fc gamma receptor IIb expression than the FO B cells.Further,the MZ B cells migrated to the FO areas upon immunization,possibly providing antigen and activating FO T cells and subsequently FO B cells.Thus,around CIA onset increased numbers of IgG anti-CII producing FO B cells was seen in the spleen,which was dominated by IgG2a-and IgG2b-positive cells.These data demonstrate that CII-reactive MZ B cells are present before and expand after CII immunization,suggesting an initiating role of MZ B cells in the development of CIA. 关 键 词：ARTHRITIS B cells collagen type II ELISPOT marginal zone mice
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