CD4^(+)CD25^(+)but not CD4^(+)Foxp3^(+) T cells as a regulatory subset in primary biliary cirrhosis

查看全文 作　　者：Dandan [1]Wang;Huayong [1]Zhang;Jun [1]Liang;Zhifeng [1]Gu;Qiang [2]Zhou;Xiangshan [2]Fan;Yayi [3]Hou;Lingyun [1]Sun

机构地区：[1]Department of Immunology and Rheumatology,The Affiliated Drum Tower Hospital of Nanjing University Medical School,Nanjing,China;[2]Department of Pathology,The Affiliated Drum Tower Hospital of Nanjing University Medical School,Nanjing,China;[3]Immunology Laboratory,Nanjing University Medical School,Nanjing,Jiangsu,China

出　　处：《Cellular & Molecular Immunology》索引2010年第7卷第6期,共6页

基　　金：by a grant from the Jiangsu Province 135 Talent Foundation(RC2007004). 摘　　要：Increasing evidence indicates a role for regulatory T cells(Tregs)in the immune response and in autoimmune diseases,but the role of Tregs and cytokines in autoimmune hepatic diseases remains largely unclear and controversial,especially in patients with primary biliary cirrhosis(PBC).This study was undertaken to investigate Tregs and different cytokines in the liver and peripheral blood of PBC patients.We found that these patients demonstrated a reduction of CD4^(+)CD25^(+) T cells but elevated CD4^(+)Foxp3^(+) T cells in peripheral blood mononuclear cells(PBMCs)and CD41 T cells.The percentage of CD4^(+)CD25^(+) T cells in PBMCs was negatively correlated with elevated plasma interferon(IFN)-c levels.A liver-specific analysis showed that the frequency of Foxp31 Tregs,transforming growth factor(TGF)-b1 and IFN-c were increased in PBC patients.Our findings suggest that an imbalance between CD4^(+)CD25^(+) Tregs and cytotoxic cytokines plays a crucial role in the pathogenesis of PBC while the role of Foxp3 needs further investigation. 关键词：CYTOKINES forkhead box P3 primary biliary cirrhosis regulatory T cells

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CD4^(+)CD25^(+)but not CD4^(+)Foxp3^(+) T cells as a regulatory subset in primary biliary cirrhosis

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