Hippo pathway in intestinal homeostasis and tumorigenesis

查看全文 作　　者：Lanfen [1]Chen;Funiu [1]Qin;Xianming [1]Deng;Joseph [2,3]Avruch;Dawang [1]Zhou

机构地区：[1]State Key Laboratory of Stress Cell Biology,School of Life Sciences,Xiamen University,Xiamen 361005,China;[2]Department of Molecular Biology,Massachusetts General Hospital,Boston,MA 02114,USA;[3]Department of Medicine,Harvard Medical School,Boston,MA 02115,USA��

出　　处：《Protein & Cell》索引2012年第3卷第4期,共6页

基　　金：supported by grants from the China’s 1000 Young Talents Program,the 111 Project of The Ministration of Education of China(No.B06016);the Fundamental Research Funds for the Central Universities of China(No.2010111079);National Natural Science Foundation of China(Grant No.81101503)and Natural Science Foundation of Fujian(No.2011J05096);supported by the RO1 awards CA136567(JA),DK17776(JA)and institutional funds.The authors have no financial conflicts to disclose. 摘　　要：The Hippo pathway plays a crucial role in controlling organ size by inhibiting cell proliferation and promoting cell death.Recent findings implicate that this pathway is involved in the process of intestinal regeneration and tumorigenesis.Here we summarize current studies for the function of the Hippo signaling pathway in intestinal homeostasis,regeneration and tumorigenesis,and the crosstalk between the Hippo signaling pathway and other major signaling pathways,i.e.Wnt,Notch and Jak/Stat signaling pathways in intestinal compartment. 关键词：Hippo/Mst1/2 YAP/Yorkie intestinal stem cells

相关文献

参考文献（51）
引证文献（4）
耦合文献（0）

参考文献(51)

引证文献(4)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Hippo pathway in intestinal homeostasis and tumorigenesis

参考文献(51)

引证文献(4)

用户提示