Functions of NKG2D in CD8^(+) T cells: an opportunity for immunotherapy

查看全文 作　　者：Kushal [1]Prajapati;Cynthia [1]Perez;Lourdes Beatriz Plaza [1]Rojas;Brianna [1]Burke;Jose A Guevara-[1]Patino

机构地区：[1]Loyola University Chicago,Oncology Institute,Maywood,IL 60153,USA

出　　处：《Cellular & Molecular Immunology》索引2018年第15卷第5期,共10页

摘　　要：Natural killer group 2 member D(NKG2D)is a type II transmembrane receptor.NKG2D is present on NK cells in both mice and humans,whereas it is constitutively expressed on CD8+T cells in humans but only expressed upon T-cell activation in mice.NKG2D is a promiscuous receptor that recognizes stress-induced surface ligands.In NK cells,NKG2D signaling is sufficient to unleash the killing response;in CD8+T cells,this requires concurrent activation of the T-cell receptor(TCR).In this case,the function of NKG2D is to authenticate the recognition of a stressed target and enhance TCR signaling.CD28 has been established as an archetype provider of costimulation during T-cell priming.It has become apparent,however,that signals from other costimulatory receptors,such as NKG2D,are required for optimal T-cell function outside the priming phase.This review will focus on the similarities and differences between NKG2D and CD28;less well-described characteristics of NKG2D,such as the potential role of NKG2D in CD8+T-cell memory formation,cancer immunity and autoimmunity;and the opportunities for targeting NKG2D in immunotherapy. 关键词：NKG2D CD28 CD8+T Cell Cancer Immunity AUTO-IMMUNITY Memory IMMUNOTHERAPY

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Functions of NKG2D in CD8^(+) T cells: an opportunity for immunotherapy

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