Chrysin promotes osteogenic differentiation via ERK/MAPK activation

查看全文 作　　者：Wenfeng [1,2]Zeng;Yan [3]Yan;Fayun [1]Zhang;Chunling [1]Zhang;Wei [1]Liang

机构地区：[1]Protein&Peptide Pharmaceutical Laboratory,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China;[2]University of the Chinese Academy of Sciences,Beijing 100049,China;[3]Department of Endodontics,Beijing Stomatological Hospital,Capital Medical University,Beijing 100050,China

出　　处：《Protein & Cell》索引2013年第4卷第7期,共9页

摘　　要：T he effect of the anti-infl ammatory fl avonoid chrysin on osteogenesis was determined in preosteoblast MC3T3-E1 cells.Results demonstrated that chrysin could induce osteogenic differentiation in the absence of other osteo-genic agents.Chrysin treatment promoted the expres-sion of transcription factors(Runx2 and Osx)and bone formation marker genes(Col1A1,OCN,and OPN)as well as enhanced the formation of mineralized nodules.During osteogenic differentiation,chrysin preferentially activated ERK1/2,but not JNK nor the p38 MAPKs.Further experi-ments with inhibitors revealed the co-treatment of U0126,PD98059,or ICI182780(a general ER antagonist)with chrysin effectively abrogated the chrysin-induced osteo-genesis and ERK1/2 activation.Thus,the effect of chrysin on osteogenesis is ERK1/2-dependent and involves ER.Therefore,chrysin has the signifi cant potential to enhance osteogenesis for osteoporosis prevention and treatment. 关键词：CHRYSIN OSTEOGENESIS ERK1/2 estrogen re-ceptor

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Chrysin promotes osteogenic differentiation via ERK/MAPK activation

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