Protein dynamics elucidated by NMR technique

查看全文 作　　者：Conggang [1]Li;Chun [1]Tang;Maili [1]Liu 机构地区：[1]Key Laboratory of Magnetic Resonance in Biological Systems,Wuhan Center for Magnetic Resonance,State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics,Wuhan Institute of Physics and Mathematics,Chinese Academy of Sciences,Wuhan 430071,China 出　　处：《Protein & Cell》索引2013年第4卷第10期,共5页 摘　　要：In 1957,Christian Anfinsen postulated his famous dogma based on the study of ribonuclease(Sela et al.,1957),stating that the amino acid sequence of a protein determines its tertiary structure,a unique and kinetically accessible energy minimum,in a given environment.As a result,determination of a global energy minimum,or the most populated structure,has been the main focus of structural biology in the ensuing half a century.With more and more structures have been determined,people have gain some insights of why protein functions,but the detailed mechanisms and the function process,or how protein functions,remains elusive. 关 键 词：elucidated STRUCTURE DYNAMICS