YB-1 stabilizes HIV-1 genomic RNA and enhances viral production

查看全文 作　　者：Xin [1,2]Mu;Wei [1,2]Li;Xinlu [1]Wang;Guangxia [1]Gao

机构地区：[1]Key Laboratory of Infection and Immunity,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China;[2]University of Chinese Academy of Sciences,Beijing 100049,China

出　　处：《Protein & Cell》索引2013年第4卷第8期,共7页

基　　金：This work was supported in part by Grants to G.G.from National Natural Science Foundation of China(Grant No.81030030);the National Basic Research Program(973 Program)(No.2012CB910203). 摘　　要：HIV-1 utilizes cellular factors for effi cient replication.The viral RNA is different from cellular mRNAs in many aspects,and is prone to attacks by cellular RNA quality control systems.To establish effective infection,the virus has evolved multiple mechanisms to protect its RNA.Here,we show that expression of the Y-box binding protein 1(YB-1)enhanced the production of HIV-1.Downregulation of endogenous YB-1 in producer cells decreased viral production.YB-1 increased viral protein expression by stabilizing HIV-1 RNAs.The stem loop 2 in the HIV-1 RNA packaging signal was mapped to be the YB-1-responsive element.Taken together,these results indicate that YB-1 stabilizes HIV-1 genomic RNA and thereby enhances HIV-1 gene expression and viral production. 关键词：Y-box binding protein 1 HIV-1 RNA stability

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YB-1 stabilizes HIV-1 genomic RNA and enhances viral production

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