Impact of type 2 diabetes mellitus on short-term and long-term outcomes of patients with esophageal squamous cell cancer undergoing resection: a propensity score analysis

查看全文 作　　者：Wang [1,2]Yao;Yuqi [1,3]Meng;Mingjian [1,4]Lu;Wenzhe [2]Fan;Jinhua [1]Huang;Jiaping [2]Li;Zhihua [1]Zhu

机构地区：[1]Sun Yat-sen University Cancer Center,State Key Laboratory of Oncology in South China,Collaborative Innovation Center for Cancer Medicine,Guangzhou 510060,China;[2]Department of Interventional Oncology,The First Affiliated Hospital,Sun Yat-sen University,No.58,Zhongshan Second Road,Guangzhou 510080,Guangdong,P.R.China;[3]Department of Thoracic Surgery,Second Hospital of Lanzhou University,Lanzhou 730030,Gansu,P.R.China;[4]Department of Radiology,Affiliated Cancer Hospital&Institute of Guangzhou Medical University,Guangzhou 510060,Guangdong,P.R.China

出　　处：《Cancer Communications》索引2018年第38卷第1期,共9页

摘　　要：Background:The association between type 2 diabetes mellitus(T2DM)and the risk of esophageal cancer remains unclear.The present study aimed to evaluate the impact of T2DM on short-term outcomes and long-term survival in patients with esophageal squamous cell cancer(ESCC).Methods:The present retrospective study included 862 patients diagnosed with ESCC between January 2001 and December 2010.Among them,280 patients had T2DM.A 1:1 propensity score-matched cohort consisting of 280 patients with and 280 without T2DM was selected from the 862 patients.The associations between T2DM and clinico-pathologic characteristics were assessed using theχ2 or Fisher’s exact test.Survival of ESCC patients with and without T2DM was calculated by using the Kaplan-Meier method and compared by using the Cox regression model between the two groups.Results:The occurrence rate of anastomotic leakage was significantly higher in patients with T2DM than in those without T2DM(P<0.001).In the subgroup with weight loss rate≤5.05%,ESCC patients with T2DM had a signifi-cant longer overall survival than did those without T2DM(P=0.003),whereas in the subgroup with weight loss rate>5.05%,the patients without T2DM showed a longer survival(P=0.001).Univariate and multivariate analysis results showed that T2DM was not an independent prognostic factor for patient survival.Conclusions:Type 2 diabetes mellitus is not an independent prognostic factor in patients with ESCC.However,the combination of T2DM with severe weight loss would be a predictor of poor prognosis. 关键词：Type 2 diabetes mellitus Esophageal cancer PROGNOSIS Overall survival

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Impact of type 2 diabetes mellitus on short-term and long-term outcomes of patients with esophageal squamous cell cancer undergoing resection: a propensity score analysis

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