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Role of (myo)fibroblasts in the development of vascular and connective tissue structure of the C38 colorectal cancer in mice

查看全文 作　　者：Edina [1]Bugyik;Vanessza [1]Szabó;Katalin [1]Dezső;András [1]Rókusz;Armanda [1]Szücs;Péter [1]Nagy;József [2]Tóvári;Viktória [4,5]László;Balázs [3,4,5,6]Döme;Sándor [1,7]Paku 高影响力作者 机构地区：[1]First Department of Pathology and Experimental Cancer Research,Sem-melweis University,Budapest,Üllőiút 26,1085,Hungary;[2]Department of Experimental Pharmacology,National Institute of Oncology,Budapest 1122,Hungary;[3]Department of Thoracic Surgery,Semmelweis University-National Institute of Oncology,Budapest 1122,Hungary.;[4]Department of Thoracic Surgery,Medical University of Vienna,Waehringer Guertel 18-20,1090 Vienna,Austria;[5]Department of Biomedical Imaging and Image-guided Therapy,Medical University of Vienna,1090 Vienna,Austria;[6]National Koranyi Institute of Pulmonology,Budapest 1122,Hungary.;[7]Tumor Progression Research Group,Hungarian Academy of Sciences-Semmelweis University,Budapest 1085,Hungary高影响力机构 出　　处：《Cancer Communications》索引2018年第38卷第1期,共11页高影响力期刊 基　　金：KD is the recipient of the Bolyai fellowship of the Hungarian Academy of Sciences and received support from the National Excellence Program(TÁMOP 4.2.4.A/1-11-1-2012-0001);BD acknowledges support from the Hungarian NRDI Office(K109626,K108465,KNN121510 and SNN114490);SP and VL acknowledge support from the Hungarian NRDI Office(ANN125583);JT acknowledges support from the National Research,Development and Innovation Office(NKFIH116295);EB is the recipient of postdoctoral fellowship from the Hungarian Academy of Sciences. 摘　　要：Background:It remains unclear if the vascular and connective tissue structures of primary and metastatic tumors are intrinsically determined or whether these characteristics are defined by the host tissue.Therefore we examined the microanatomical steps of vasculature and connective tissue development of C38 colon carcinoma in different tissues.Methods:Tumors produced in mice at five different locations(the cecal wall,skin,liver,lung,and brain)were ana-lyzed using fluorescent immunohistochemistry,electron microscopy and quantitative real-time polymerase chain reaction.Results:We found that in the cecal wall,skin,liver,and lung,resident fibroblasts differentiate into collagenous matrix-producing myofibroblasts at the tumor periphery.These activated fibroblasts together with the produced matrix were incorporated by the tumor.The connective tissue development culminated in the appearance of intratumoral tissue columns(centrally located single microvessels embedded in connective tissue and smooth muscle actin-expressing myofibroblasts surrounded by basement membrane).Conversely,in the brain(which lacks fibroblasts),C38 metasta-ses only induced the development of vascularized desmoplastic tissue columns when the growing tumor reached the fibroblast-containing meninges.Conclusions:Our data suggest that the desmoplastic host tissue response is induced by tumor-derived fibrogenic molecules acting on host tissue fibroblasts.We concluded that not only the host tissue characteristics but also the tumor-derived fibrogenic signals determine the vascular and connective tissue structure of tumors. 关 键 词：Metastasis VASCULATURE MYOFIBROBLASTS Incorporation
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