Control of Aggregate Size of Polyethyleneimine-Coated Magnetic Nanoparticles for Magnetofection

查看全文 作　　者：Xiaoliang [1]Wang;Linzhu [1]Zhou;Yongjie [1]Ma;Xu [1]Li;Hongchen [1]Gu

机构地区：[1]Nano Biomedicine Research Center,Med-X Research Institute,Shanghai Jiaotong University,1954 Huashan Road,Shanghai 200030,China

出　　处：《Nano Research》索引2009年第2卷第5期,共8页

基　　金：This work was supported by National 973 Program(2006CBON0300);International Cooperation Project(20080068,075207012). 摘　　要：Using magnetic nanoparticles to enhance gene transfection,a recently developed technique termed magnetofection,has been shown to be a powerful technology in gene delivery.The most widely used magnetic nanoparticles in this area are those coated with polyethyleneimine,which is a well known non-viral transfection agent.In this article,we report methods to control the aggregate size of polyethyleneimine-coated magnetite particles.These particles were then used to enhance transfection of green fluorescent protein(GFP)into NIH 3T3 cells in vitro.We find that the aggregate size of the particles has a great effect on their performance in magnetofection,with less aggregated magnetic particles being more effective in enhancing the gene transfection. 关键词：MAGNETOFECTION TRANSFECTION magnetic nanoparticles polyethyleneimine(PEI)

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Control of Aggregate Size of Polyethyleneimine-Coated Magnetic Nanoparticles for Magnetofection

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