Salvianolic acid C potently inhibits SARS-CoV-2 infection by blocking the formation of six-helix bundle core of spike protein

查看全文 作　　者：Chan [1]Yang;Xiaoyan [2]Pan;Xinfeng [1]Xu;Chen [1]Cheng;Yuan [1]Huang;Lin [1]Li;Shibo [3]Jiang;Wei [1]Xu;Gengfu [2]Xiao;Shuwen [1,4]Liu

机构地区：[1]Guangdong Provincial Key Laboratory of New Drug Screening,School of Pharmaceutical Sciences,Southern Medical University,Guangzhou,China;[2]State Key Laboratory of Virology,Wuhan Institute of Virology,Center for Biosafety Mega-Science,Chinese Academy of Sciences,Wuhan,China;[3]Key Laboratory of Medical Molecular Virology(MOE/NHC/CAMS),School of Basic Medical Sciences,Fudan-Jinbo Joint Research Center,Fudan University,Shanghai,China;[4]State Key Laboratory of Organ Failure Research,Guangdong Provincial Institute of Nephrology,Southern Medical University,Guangzhou,China

出　　处：《Signal Transduction and Targeted Therapy》索引2020年第5卷第1期,共3页

摘　　要：Dear Editor,The pandemic of COVID-19 caused by SARS-CoV-2 infection has posed a serious threat to global public health and the economy.Up to now,although several potentially effective antiviral drugs are under evaluating in clinical trials around the world,1 there are still no specific antiviral countermeasures beyond supportive therapies have been established.We herein report that the hydrophilic compound Salvianolic acid C(Sal-C)from Danshen,a traditional Chinese medicine(TCM),potently inhibit SARS-CoV-2 infection by blocking the formation of six-helix bundle(6-HB)core of spike(S)protein. 关键词：INFECTION DRUGS BUNDLE

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Salvianolic acid C potently inhibits SARS-CoV-2 infection by blocking the formation of six-helix bundle core of spike protein

参考文献(5)

引证文献(14)

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