Overcoming cancer therapeutic bottleneck by drug repurposing

查看全文 作　　者：Zhe [1]Zhang;Li [1]Zhou;Na [1]Xie;Edouard [2]CNice;Tao [3,4]Zhang;Yongping [5,6]Cui;Canhua [1,7]Huang

机构地区：[1]State Key Laboratory of Biotherapy and Cancer Center,West China Hospital,and West China School of Basic Medical Sciences&Forensic Medicine,Sichuan University,and Collaborative Innovation Center for Biotherapy,610041 Chengdu,China;[2]Department of Biochemistry and Molecular Biology,Monash University,Clayton,VIC,Australia;[3]The School of Biological Science and Technology,Chengdu Medical College,610083 Chengdu,China;[4]Department of Oncology,The Second Affiliated Hospital of Chengdu Medical College,China National Nuclear Corporation 416 Hospital,Chengdu,610051 Sichuan,China;[5]Cancer Institute,Peking University Shenzhen Hospital,Shenzhen Peking University—the Hong Kong University of Science and Technology(PKU-HKUST)Medical Center,and Cancer Institute,Shenzhen Bay Laboratory Shenzhen,518035 Shenzhen,China;[6]Department of Pathology&Shanxi Key Laboratory of Carcinogenesis and Translational Research on Esophageal Cancer,Shanxi Medical University,Taiyuan,030001 Shanxi,China;[7]School of Basic Medical Sciences,Chengdu University of Traditional Chinese Medicine,Chengdu,611137 Sichuan,China

出　　处：《Signal Transduction and Targeted Therapy》索引2020年第5卷第1期,共25页

基　　金：supported by grants from the Chinese NSFC(nos.81821002,81790251,and 81773143);Guangdong Basic and Applied Basic Research Foundation(2019B030302012). 摘　　要：Ever present hurdles for the discovery of new drugs for cancer therapy have necessitated the development of the alternative strategy of drug repurposing,the development of old drugs for new therapeutic purposes.This strategy with a cost-effective way offers a rare opportunity for the treatment of human neoplastic disease,facilitating rapid clinical translation.With an increased understanding of the hallmarks of cancer and the development of various data-driven approaches,drug repurposing further promotes the holistic productivity of drug discovery and reasonably focuses on target-defined antineoplastic compounds.The“treasure trove”of non-oncology drugs should not be ignored since they could target not only known but also hitherto unknown vulnerabilities of cancer.Indeed,different from targeted drugs,these old generic drugs,usually used in a multi-target strategy may bring benefit to patients.In this review,aiming to demonstrate the full potential of drug repurposing,we present various promising repurposed non-oncology drugs for clinical cancer management and classify these candidates into their proposed administration for either mono-or drug combination therapy.We also summarize approaches used for drug repurposing and discuss the main barriers to its uptake. 关键词：DRUGS THERAPEUTIC classify

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Overcoming cancer therapeutic bottleneck by drug repurposing

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