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A MEMS ultrasound stimulation system for modulation of neural circuits with high spatial resolution in vitro

查看全文 作　　者：Jungpyo [1,2]Lee;Kyungmin [1]Ko;Hyogeun [1,3]Shin;Soo-Jin [4,5,6]Oh;CJustin [4,6,7,8]Lee;Namsun [1]Chou;Nakwon [1,3]Choi;Min Tack [1]Oh;Byung Chul [1]Lee;Seong Chan [2]Jun;Il-Joo [1]Cho 高影响力作者 机构地区：[1]Center for BioMicrosystems,Brain Science Institute,Korea Institute of Science and Technology(KIST),Seoul 02792,Republic of Korea;[2]School of Mechanical Engineering,Yonsei University,Seoul 03722,Republic of Korea;[3]Division of Bio-Medical Science&Technology,KIST School,Korea University of Science and Technology(UST),Seoul 02792,Republic of Korea;[4]Center for Neuroscience,Brain Science Institute,Korea Institute of Science and Technology(KIST),Seoul 02792,Republic of Korea;[5]Convergence Research Center for Diagnosis,Treatment,and Care System of Dementia,Korea Institute of Science and Technology(KIST),Seoul 02792,Republic of Korea;[6]Center for Glia-Neuron Interaction,Korea Institute of Science and Technology(KIST),Seoul 02792,Republic of Korea;[7]KU-KIST Graduate School of Converging Science and Technology,Korea University,Seoul 02841,Republic of Korea;[8]Division of Bio-Medical Science&Technology,KIST School,Korea University of Science and Technology,UST,Yuseong-gu,Daejeon 34113,Republic of Korea高影响力机构 出　　处：《Microsystems & Nanoengineering》索引2019年第5卷第1期,共11页高影响力期刊 基　　金：This work was supported by the Brain Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Science and ICT(NRF-2017M3C7A1028854);Bio&Medical Technology Development Program of the National Research Foundation(NRF)funded by the Ministry of Science&ICT(NRF-2017M3A9B3061319);This work was also supported by the KIST Institutional Program(2E29200). 摘　　要：Neuromodulation by ultrasound has recently received attention due to its noninvasive stimulation capability for treating brain diseases.Although there have been several studies related to ultrasonic neuromodulation,these studies have suffered from poor spatial resolution of the ultrasound and low repeatability with a fixed condition caused by conventional and commercialized ultrasound transducers.In addition,the underlying physics and mechanisms of ultrasonic neuromodulation are still unknown.To determine these mechanisms and accurately modulate neural circuits,researchers must have a precisely controllable ultrasound transducer to conduct experiments at the cellular level.Herein,we introduce a new MEMS ultrasound stimulation system for modulating neurons or brain slices with high spatial resolution.The piezoelectric micromachined ultrasonic transducers(pMUTs)with small membranes(submm membranes)generate enough power to stimulate neurons and enable precise modulation of neural circuits.We designed the ultrasound transducer as an array structure to enable localized modulation in the target region.In addition,we integrated a cell culture chamber with the system to make it compatible with conventional cell-based experiments,such as in vitro cell cultures and brain slices.In this work,we successfully demonstrated the functionality of the system by showing that the number of responding cells is proportional to the acoustic intensity of the applied ultrasound.We also demonstrated localized stimulation capability with high spatial resolution by conducting experiments in which cocultured cells responded only around a working transducer. 关 键 词：NEURAL STIMULATION SYSTEM
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