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PRPF19 promotes tongue cancer growth and chemoradiotherapy resistance

查看全文 作　　者：Yihong [1,2]He;Changhao [1]Huang;Kaimei [1]Cai;Pei [2]Liu;Xueyan [1,2]Chen;Yi [1]Xu;Zhengnan [1,3]Ming;Qingqing [1,2]Liu;Qiongxuan [2]Xie;Xue [1,3]Xia;Yangqing [1,2]Sun;Junli [1]Luo;Rui [2]Wei 高影响力作者 机构地区：[1]Department of General Surgery and the Hunan Provincial Key Lab of Precision Diagnosis and Treatment for Gastrointestinal Tumor,Xiangya Hospital,Central South University,Changsha 410008,China;[2]Department of Oncology,Xiangya Hospital,Central South University,Changsha 410008,China;[3]Department of Biochemistry and Molecular Biology,School of Life Sciences,Central South University,Changsha 410008,China高影响力机构 出　　处：《Acta Biochimica et Biophysica Sinica》索引2021年第53卷第7期,共10页高影响力期刊 基　　金：This work was supported by the grants from the National Natural Science Foundation of China(Nos.81974469 and 81672635);Hunan Provincial Key Program for Research and Development(No.2018SK21214);a grant of the Postgraduate Independent Exploration and Innovation Project of Central South University of China(No.2020zzts862). 摘　　要：Pre-mRNA processing factor 19(PRPF19)is a multifaceted protein and participates in DNA damage response and pre-mRNA processing.The role of PRPF19 in cancer is unclear.Here,we report that the expression of PRPF19 in human tongue cancer is associated with unfavorable prognosis.Overexpression of PRPF19 promotes while knockdown of PRPF19 inhibits tongue cancer cell migration,proliferation,and tumor growth.Overexpression of PRPF19 increases the resistance of tongue cancer cells to radiation and cisplatin treatment.Furthermore,PRPF19 regulates the expression of solute carrier family 40 member 1(SLC40A1)and mono-ADP ribosylhydrolase 2(MACROD2),knockdown of SLC40A1 or MACROD2 decreases the sensitivity of tongue cancer cells to radiation and cisplatin treatment.Thus,our results establish a key role of PRPF19 in tongue cancer growth and chemoradiotherapy resistance,targeting PRPF19 would be an effective therapeutic strategy for tongue cancer,especially for those resistant to chemoradiotherapy. 关 键 词：PRPF19 tongue cancer chemoradiotherapy resistance RECURRENCE
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