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Defect-rich titanium nitride nanoparticle with high microwaveacoustic conversion efficiency for thermoacoustic imaging-guided deep tumor therapy

查看全文 作　　者：Zhujun [1,2]Wu;Fanchu [1,2]Zeng;Le [1,2]Zhang;Shuxiang [1,2]Zhao;Linghua [1,2]Wu;Huan [1,2]Qin;Da [1,2]Xing 高影响力作者 机构地区：[1]MOE Key Laboratory of Laser Life Science&Institute of Laser Life Science,College of Biophotonics,South China Normal University,Guangzhou 510631,China;[2]Guangdong Provincial Key Laboratory of Laser Life Science,College of Biophotonics,South China Normal University,Guangzhou 510631,China高影响力机构 出　　处：《Nano Research》索引2021年第14卷第8期,共11页高影响力期刊 基　　金：supported by the National Natural Science Foundation of China(No.62075066);the Science and Technology Planning Project of Guangdong Province,China(Nos.2019A1515012054);the Scientific and Technological Planning Project of Guangzhou City(No.201805010002);the Science and Technology Program of Guangzhou(No.2019050001). 摘　　要：Pulse microwave excite thermoacoustic(TA)shockwave to destroy tumor cells in situ.This has promising applications for precise tumor therapy in deep tissue.Nanoparticle(NP)with high microwave-acoustic conversion is the key to enhance the efficiency of therapy.In this study,we firstly developed defect-rich titanium nitride nanoparticles(TiN NPs)for pulse microwave excited thermoacoustic(MTA)therapy.Due to a large number of local structural defects and charge carriers,TiN NPs exhibit excellent electromagnetic absorption through the dual mechanisms of dielectric loss and resistive loss.With pulsed microwave irradiation,it efficiently converts the microwave energy into shockwave via thermocavitation effect,achieving localized mechanical damage of mitochondria in the tumor cell and yielding a precise antitumor effect.In addition to the therapeutic function,the NP-mediated TA process also generates images that provide valuable information,including tumor size,shape,and location for treatment planning and monitoring.The experimental results showed that the TiN NPs could be efficiently accumulated in the tumor via intravenous infusion.With the deep tissue penetration characteristics of microwave,the proposed TiN-mediated MTA therapy effectively and precisely cures tumors in deep tissue without any detectable side effects.The results indicated that defect-rich TiN NPs are promising candidates for tumor therapy. 关 键 词：defect-rich titanium nitride nanoparticles pulse microwave excited thermoacoustic therapy thermoacoustic imaging mitochondria-targeting deep-seated tumor model
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