A retrospective survey of Brucella melitensis human infection in Hainan Province,China

查看全文 作　　者：Shuyi [1]Ma;Xuming [2]Wang;Miao [3]Wang;Zhiguo [4]Liu;Zhenjun [4]Li

机构地区：[1]School of Medical Technology,Baotou Medical College,Baotou 014040,China;[2]Hainan Provincial People's Hospital,Haikou 570311,China;[3]Ulanqab Central for Endemic Disease Control and Prevention,Jining 012000,China;[4]State Key Laboratory for Infectious Disease Control and Prevention,National Institute for Communicable Disease Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing 102206,China.

出　　处：《Biosafety and Health》索引2021年第3卷第3期,共5页

基　　金：supported by the National Key R&D Program of China(Grant No.2018ZX10734401,2018ZX10734404,2019YFC1200601, 2019YFC1200705);the Natural Science Fund of Hainan Province(No.817319)。 摘　　要：In China,brucellosis has spread from the northern provinces to the southern coastal area,and Brucella melitensis has become the overwhelmingly dominant species nationwide.Although human Brucellosis cases have been reported in many parts of Hainan Province,investigations into the source of infection have been rare.In this case,we have used the techniques of bacteriology,genome sequencing,and WGS-SNP to investigate the source of infection on a patient with a traveling history between Hainan and Inner Mongolia autonomous regions.We collected a 5mL blood sample under sterile conditions from this suspected case of Brucellosis infection and incubated it in a culture bottle.A week later,Brucella colonies were purified and identified under the standard bacteriology procedures to show that the strain appeared as B.melitensis bv.3.Subsequently,a draft genome sequencing of this strain was obtained.AWGS-SNP comparison analysis of Chinese B.melitensis selected(n=36)fromGenBank revealed that the strain in this studywas more similar to the strains isolated from China's northern parts,especially those from the Inner Mongolia Autonomous Region.These data indicated that the source of infection of the patient was in the Inner Mongolia Autonomous Region,but the actual location where this patient became infected was unclear.We suggest that travelers from the southern part of China be cautious when visiting the traditional endemic areas of Brucellosis. 关键词：Brucella melitensis BIOTYPING Draft genome sequence SNP

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A retrospective survey of Brucella melitensis human infection in Hainan Province,China

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