Preliminary Seroepidemiological survey of dengue infections in Pakistan,2009-2014

查看全文 作　　者：Muhammad [1,2]Suleman;Hyeong-Woo [3]Lee;Syed Sohail Zahoor [2]Zaidi;Muhammad Masroor [2]Alam;Nadia [2]Nisar;Uzma Bashir [2]Aamir;Salmaan [2]Sharif;Shahzad [2]Shaukat;Adnan [2]Khurshid;Mehar [2]Angez;Massab [2]Umair;Ghulam [2]Mujtaba;Rani [1]Faryal 机构地区：[1]Department of Microbiology,Quaid-i-Azam University,Islamabad,Pakistan;[2]Department of Virology,National Institute of Health,Islamabad,Pakistan;[3]Department of Tropical Medicine and Parasitology,Inha University School of Medicine,Incheon 22212,Republic of Korea 出　　处：《Infectious Diseases of Poverty》索引2017年第6卷第1期,共7页 基　　金：The authors funded the study themselves. 摘　　要：Background:Dengue virus is the causative agent of dengue fever,a vector borne infection which causes selflimiting to life threatening disease in humans.A sero-epidemiological study was conducted to understand the current epidemiology of dengue virus in Pakistan which is now known as a dengue endemic country after its first reported outbreak in 1994.Methods:To investigate the prevalence of dengue virus in Pakistan during 2009-2014,a total of 9,493 blood samples were screened for the detection of anti-dengue IgM antibodies using ELISA.Clinical and demographic features available with hospital records were reviewed to ascertain mortalities related to dengue hemorrhagic shock syndrome.Results:Out of 9,493 samples tested,37%(3,504)were found positive for anti-dengue IgM antibodies.Of the seropositive cases,73.6%(2,578/3,504)were male and 26.4%(926/3,504)were female.The highest number(382/929;41.1%)of sero-positive cases was observed among the individuals of age group 31-40 years.The highest number of symptomatic cases was reported in October(46%;4,400/9,493),and the highest number of sero-positive cases among symptomatic cases was observed in November(45.7%;806/1,764).Mean annual patient incidence(MAPI)during 2009-2014 in Pakistan remained 0.30 with the highest annual patient incidence(11.03)found in Islamabad.According to the available medical case record,472 dengue related deaths were reported during 2009-2014.Conclusion:The data from earlier reports in Pakistan described the dengue virus incidence from limited areas of the country.Our findings are important considering the testing of clinical samples at a larger scale covering patients of vast geographical regions and warrants timely implementation of dengue vector surveillance and control programs.Trial registration number:It is an epidemiological research study,so trial registration is not required. 关 键 词：Dengue Virus EPIDEMIOLOGY Pakistan IgM ELISA VECTOR