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Usefulness of interferon-γrelease assay for the diagnosis of sputum smear-negative pulmonary and extra-pulmonary TB in Zhejiang Province,China

查看全文 作　　者：Lei [1]Ji;Yong-Liang [2]Lou;Zhong-Xiu [3]Wu;Jin-Qin [1]Jiang;Xing-Li [1]Fan;Li-Fang [1]Wang;Xiao-Xiang [1]Liu;Peng [1]Du;Jie [4,5]Yan;Ai-Hua [1,2]Sun 高影响力作者 机构地区：[1]Department of Basic Medicine,Hangzhou Medical College,Hangzhou 310053,Zhejiang,People’s Republic of China;[2]School of Laboratory Medical Science and Life Science,Wenzhou Medical University,Wenzhou 325035,Zhejiang,People’s Republic of China;[3]Zhejiang Blood Center,Hangzhou 310006,Zhejiang,People’s Republic of China;[4]Division of Basic Medical Microbiology,State Key Laboratory for Diagnosis and Treatment of Infectious Diseases,First Affiliated Hospital of Zhejiang University,Hangzhou 310003,Zhejiang,People’s Republic of China;[5]Department of Medical Microbiology and Parasitology,College of Medicine,Zhejiang University,Hangzhou 310058,Zhejiang,People’s Republic of China高影响力机构 出　　处：《Infectious Diseases of Poverty》索引2017年第6卷第1期,共5页高影响力期刊 基　　金：This work was supported by Grants from the National Natural Sciences Foundation of China(81271893);the Natural Science Foundation of Zhejiang Province(LY12H19002);Zhejiang Provincial Program for the Cultivation of High-level Innovative Health Talents,the Scientific Research Foundation of the Education Department of Zhejiang Province(Y201534356);the Natural Science Foundation of Zhejiang Medical College(2014B01);Visiting Engineer Program of the Education Department of Zhejiang Province(FG2014011). 摘　　要：Background:Quick diagnosis of smear-negative pulmonary tuberculosis(TB)and extra-pulmonary TB are urgently needed in clinical diagnosis.Our research aims to investigate the usefulness of the interferon-γrelease assay(IGRA)for the diagnosis of smear-negative pulmonary and extra-pulmonary TB.Methods:We performed TB antibody and TB-IGRA tests on 389 pulmonary TB patients(including 120 smear-positive pulmonary TB patients and 269 smear-negative pulmonary TB patients),113 extra-pulmonary TB patients,81 patients with other pulmonary diseases and 100 healthy controls.Blood samples for the TB-Ab test and the TB-IGRA were collected,processed,and interpreted according to the manufacturer’s protocol.Results:The detection ratio of smear-positive pulmonary TB patients and smear-negative pulmonary TB patients were 90.8%(109 of 120)and 89.6%(241 of 269),respectively.There was no statistically significant difference of its performance between these two sample sets(P>0.05).The detection ratio of positive TB patients and extra-pulmonary TB patients were 90.0%(350 of 389)and 87.6%(99 of 113),respectively,which was not significantly different(P>0.05).Conclusions:In this work,the total detection ratio using TB-IGRA was 89.4%,therefore TB-IGRA has diagnostic values in smear-negative pulmonary TB and extra-pulmonary TB diagnosis. 关 键 词：Interferon-gamma release assay Smear-negative pulmonary TB Extra-pulmonary TB
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