Estimating the prevalence of schistosomiasis japonica in China:a serological approach

查看全文 作　　者：Xin-Yao [1,2,3]Wang;Jing [4]Xu;Song [1,2,3]Zhao;Wei [1,2,3]Li;Jian-Feng [1,2,3]Zhang;Jian [1,2,3]He;Ashley [3]M.Swing;Kun [1,2,3]Yang

机构地区：[1]Jiangsu Institute of Parasitic Diseases,Yangxiang117#,Meiyuan,Wuxi 214064,Jiangsu,China;[2]Key Laboratory on Technology for Parasitic Disease Prevention and Control,Ministry of Health,Jiangsu Provincial Key Laboratory on the Molecular Biology of Parasites,Yangxiang117#,Meiyuan,Wuxi 214064,Jiangsu,China;[3]Public Health Research Center,Jiangnan University,Jiangsu,Sheng,China;[4]National Institute of Parasitic Diseases,Chinese Center for Disease Control and Prevention,Shanghai,China

出　　处：《Infectious Diseases of Poverty》索引2018年第7卷第1期,共10页

基　　金：This project was supported by the National S&T Major Program(grant no.2012ZX10004220);Project of National Natural Science Foundation of China(No.81101275);Capacity improvement project of Jiangsu Public Welfare Institute(No.BM2015024). 摘　　要：Background:The prevalence of schistosomiasis japonica has decreased significantly,and the responses changing from control to elimination in Jiangsu Province,P.R.China.How to estimate the change in prevalence of schistosomiasis using only serological data will be important and useful.Methods:We collected serum samples from 2011 to 2015 to build a serum bank from Dantu County of Jiangsu,China.Serum samples were detected by enzyme-linked immunosorbent assay(ELISA),the positive rate and optical density(OD)value were obtained.The Bayesian model including the prior information of sensitivity and specificity of ELISA was established,and the estimated infection rates were obtained for different years,genders and age groups.Results:There was no significant difference in the mean OD between different years and genders,but there was a significant difference between the different age groups.There were statistically significant differences in the positive rate for different years and age groups,but no significant difference at different genders.The estimated infection rate for the five years was 1.288,1.456,1.032,1.485 and 1.358%,respectively.There was no significant difference between different years and between genders,but a significant difference between different age groups.Conclusions:The risk of schistosomiasis transmission in this area still exists,and risk monitoring of schistosomiasis should be strengthened. 关键词：Enzyme-linked immunosorbent assay(ELISA) Bayesian statistics Schistosomiasis japonica Sensitivity SPECIFICITY Estimated infection rate

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Estimating the prevalence of schistosomiasis japonica in China:a serological approach

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