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The expression of COX-2 and VEGF in mixed grafting of sheepskin and autoskin in rats

查看全文 作　　者：Mingjuan [1]Gu;Lingfeng [2]Wang;Zhihui [2]Hou 高影响力作者 机构地区：[1]Department of Plastic Surgery,The Third Affiliated Hospital of Inner Mongolia Medical University,Baotou,China;[2]Department of Burn,The Third Affiliated Hospital of Inner Mongolia Medical University,Baotou,China高影响力机构 出　　处：《Discussion of Clinical Cases》索引2015年第2卷第3期,共6页高影响力期刊 摘　　要：Objective:To investigate the expression of cycloxygenase-2(COX-2),and vascular endothelial growth factor(VEGF)by using immunohistochemistry method and observe the changes of histological structure between the all skin group and the xenoskin(sheepskin)group,and explore the effect of the xenoskin(sheepskin)which is a kind of covering of autogenous microskin grafting.Methods:A total of 180 Wistar healthy male rats were randomly divided into 3 groups:the autoskin group(the control group),the alloskin group and the xenoskin group(the sheepskin group),with 60 rats in each group.By using immunohistochemistry method,the expression of COX-2 and VEGF were revealed on 3,5,7,14,21 and 28 d,with 10 executed rats in each group on each time points,and the structure of histology was observed by light microscope.Results:There were obvious difference of expression of COX-2 and VEGF on wound in the autoskin group compared with other two groups(p<.01);but there were no differences between the alloskin group and xenoskin group(p>.05).Observed on light microscope,the paralleled collagen and elastic fiber appeared in the autoskin group on 14 post-transplantation days,but they appeared in the alloskin group and the xenoskin group only on 21 post-transplantation days.Conclusions:There were no differences of the expression of COX-2 and VEGF in the alloskin group and the xenoskin group,which provided clinical theoretical basis on sheepskin as a substitute for the alloskin to cover autogenous microskin. 关 键 词：SHEEPSKIN ANGIOGENESIS Cycloxygenase-2 Vascular endothelial growth factor
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