Effects of platelet-rich plasma on in vitro proliferation and migration of fibroblasts from human chronic refractory wound granulation tissue

查看全文 作　　者：Tie-ning [1,2]Zhang;Quan [2]Li;Te [2]Ba;Tian-xi [1,2]Shao;Fang [2]Li;Ling-feng [2]Wang

机构地区：[1]Baotou Medical College of Inner Mongolia University of Science and Technology,Baotou,Inner Mongolia,China;[2]Department of Burns,Baogang Hospital,Baotou,Inner Mongolia,China

出　　处：《Discussion of Clinical Cases》索引2021年第8卷第1期,共5页

摘　　要：Objective:To observe the effects of platelet-rich plasma(PRP)on in vitro proliferation and migration of fibroblasts from human chronic refractory wound granulation tissue.Methods:Fibroblasts were separated from human chronic refractory wound granulation tissue and then were identified.The obtained fibroblasts were divided into fetal bovine serum(FBS)group,hydrogel group and PRP group,and the three groups were cultured with culture mediums containing FBS,hydrogel and PRP respectively,in order to observe the growth of fibroblasts.The wound scratch assay was used to observe the migration of fibroblasts.Results:PRP group had more fibroblasts than FBS group and hydrogel group since Day 5 of culture,and exhibited greater fibroblast scratch migration area than FBS group on 48 h and 72 h of wound scratch assay(all p<.05).Conclusions:Compared with FBS,human fibroblasts cultured by PRP can more effectively promote the proliferation and migration of fibroblasts. 关键词：FIBROBLAST Chronic refractory wound Granulation tissue Platelet-rich plasma Cell proliferation Cell migration In vitro

相关文献

参考文献（15）
引证文献（1）
耦合文献（186）

参考文献(15)

引证文献(1)

耦合文献(186)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Effects of platelet-rich plasma on in vitro proliferation and migration of fibroblasts from human chronic refractory wound granulation tissue

参考文献(15)

引证文献(1)

耦合文献(186)

用户提示