Role of autophagy in gastric carcinogenesis

查看全文 作　　者：Apostolis [1,2,3]Papaefthymiou;Gregory [4]Christodoulidis;Apostolos [1]Koffas;Michael [5]Doulberis;Stergios A [2]Polyzos;Anastasios [1]Manolakis;Spyros [1]Potamianos;Andreas [1]Kapsoritakis;Jannis [3]Kountouras

机构地区：[1]Department of Gastroenterology,University Hospital of Larissa,Larissa 41110,Thessaly,Greece;[2]First Laboratory of Pharmacology,Aristotle University of Thessaloniki,Thessaloniki 54124,Macedonia,Greece;[3]Department of Medicine,Second Medical Clinic,Aristotle University of Thessaloniki,Ippokration Hospital,Thessaloniki 54642,Macedonia,Greece;[4]Department of Surgery,University Hospital of Larissa,Larissa 41110,Thessaly,Greece;[5]Division of Gastroenterology and Hepatology,Medical University Department,Kantonsspital Aarau,Aarau 5001,Switzerland

出　　处：《World Journal of Gastrointestinal Oncology》索引2021年第13卷第10期,共19页

摘　　要：Gastric cancer represents a common and highly fatal malignancy,and thus a pathophysiology-based reconsideration is necessary,given the absence of efficient therapeutic regimens.In this regard,emerging data reveal a significant role of autophagy in gastric oncogenesis,progression,metastasis and chemoresistance.Although autophagy comprises a normal primordial process,ensuring cellular homeostasis under energy depletion and stress conditions,alterations at any stage of the complex regulatory system could stimulate a tumorigenic and promoting cascade.Among others,Helicobacter pylori infection induces a variety of signaling molecules modifying autophagy,during acute infection or after chronic autophagy degeneration.Subsequently,defective autophagy allows malignant transformation and upon cancer establishment,an overactive autophagy is stimulated.This overexpressed autophagy provides energy supplies and resistance mechanisms to gastric cancer cells against hosts defenses and anticancer treatment.This review interprets the implicated autophagic pathways in normal cells and in gastric cancer to illuminate the potential preventive,therapeutic and prognostic benefits of understanding and intervening autophagy. 关键词：Gastric cancer AUTOPHAGY Helicobacter pylori CHEMORESISTANCE PROGNOSIS

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Role of autophagy in gastric carcinogenesis

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