TRIM31 facilitates K27-linked polyubiquitination of SYK to regulate antifungal immunity

查看全文 作　　者：Xueer [1]Wang;Honghai [1]Zhang;Zhugui [1]Shao;Wanxin [1]Zhuang;Chao [1]Sui;Feng [1]Liu;Xiaorong [1]Chen;Jinxiu [1]Hou;Lingli [1]Kong;Hansen [1]Liu;Yi [1]Zheng;Bingyu [1]Liu;Tian [2]Chen;Lei [1]Zhang;Xinming [3]Jia;Chengjiang [1]Gao

机构地区：[1]Shandong Provincial Key Laboratory of Infection and Immunity&Department of Immunology,School of Biomedical Sciences,Shandong University,Jinan,Shandong,China;[2]Department of Pathogenic Biology,School of Biomedical Sciences,Shandong University,Jinan,Shandong,China;[3]Clinical Medicine Scientific and Technical Innovation Center,Shanghai Tenth People’s Hospital,Tongji University School of Medicine,Shanghai,China

出　　处：《Signal Transduction and Targeted Therapy》索引2021年第6卷第9期,共15页

基　　金：This work was supported by grants from the National Natural Science Foundation of China(81930039,31730026,81525012);the Key Research and Development Projects of Shandong Province(2019GSF108133). 摘　　要：Spleen tyrosine kinase(SYK)is a non-receptor tyrosine kinase,which plays an essential role in both innate and adaptive immunity.However,the key molecular mechanisms that regulate SYK activity are poorly understood.Here we identified the E3 ligase TRIM31 as a crucial regulator of SYK activation.We found that TRIM31 interacted with SYK and catalyzed K27-linked polyubiquitination at Lys375 and Lys517 of SYK.This K27-linked polyubiquitination of SYK promoted its plasma membrane translocation and binding with the C-type lectin receptors(CLRs). 关键词：SYK IMMUNITY UBIQUITIN

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TRIM31 facilitates K27-linked polyubiquitination of SYK to regulate antifungal immunity

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