Dynamic landscape mapping of humoral immunity to SARS-CoY-2 identifies non-structural protein antibodies associated with the survival of critical COVID-19 patients

查看全文 作　　者：Linlin [1]Cheng;Xiaomei [2]Zhang;Yu [1]Chen;Dan [2]Wang;Dong [1]Zhang;Songxin [1]Yan;Hongye [2]Wang;Meng [1]Xiao;Te [2]Liang;Haolong [1]Li;Meng [2]Xu;Xin [1]Hou;jiayu [2]Dai;Xian [1]Wu;Mingyuan [2]Li;Minya [1]Lu;Dong [1]Wu;Ran [1]Tian;Jing [1]Zhao;Yan [1]Zhang;Wei [1]Cao;Jinglan [1]Wang;Xiaowei [1]Yan;Xiang [1]Zhou;Zhengyin [1]Liu;Yingchun [1]Xu;Fuchu [2]He;Yongzhe [1]Li;Xiaobo [2]Yu;Shuyang [1]Zhang

机构地区：[1]Department of Clinical Laboratory,State Key Laboratory of Complex Severe and Rare Diseases,Peking Union Medical College Hospital,Chinese Academy of Medical Science and Peking Union Medical College,Beijing,China;[2]State Key Laboratory of Proteomics,Beijing Proteome Research Center,National Center for Protein Sciences-Beijing(PHOENIX Center),Beijing Institute of Lifeomics,Beijing,China

出　　处：《Signal Transduction and Targeted Therapy》索引2021年第6卷第9期,共14页

基　　金：This research was supported by grants from the National Key R&D Program of China(2020YFC0861000,2020YFE0202200,2018YFE0207300);Beijing Municipal Science&Technology Commission(Z211100002521021);National Natural Science Foundation of China Grants(81671618,81871302,81673040,31870823);CAMS Innovation Fund for Medical Sciences(CIFMS)(2020-I2M-COV19-001,2017-I2M-3-001,2017-I2M-B&R-01,2019-I2M-5-063);the State Key Laboratory of Proteomics(SKLP-C202001,SKLP-0201703,SKLP-K201505);the Beijing Municipal Education Commission and the National Program on Key Basic Research Project(2018YFA0507503,2017YFC0906703,2018ZX09733003);This work is supported by Beijing Key Clinical Specialty for Laboratory Medicine-Excellent Project(No.ZK201000)。 摘　　要：A comprehensive analysis of the humoral immune response to the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is essential in understanding COVID-19 pathogenesis and developing antibody-based diagnostics and therapy.In this work,we performed a longitudinal analysis of antibody responses to SARS-CoV-2 proteins in 104 serum samples from 49 critical COVID-19 patients using a peptide-based SARS-CoV-2 proteome microarray.Our data show that the binding epitopes of IgM and IgG antibodies differ across SARS-CoV-2 proteins and even within the same protein. 关键词：IMMUNITY ANTIBODIES PATIENTS

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Dynamic landscape mapping of humoral immunity to SARS-CoY-2 identifies non-structural protein antibodies associated with the survival of critical COVID-19 patients

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