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Effective and biocompatible antibacterial surfaces via facile synthesis and surface modification of peptide polymers

查看全文 作　　者：Ziyi [1]Lu;Yueming [1]Wu;Zihao [1]Cong;Yuxin [1]Qian;Xue [1]Wu;Ning [1]Shao;Zhongqian [1]Qiao;Haodong [1]Zhang;Yunrui [1]She;Kang [1]Chen;Hengxue [2]Xiang;Bin [2]Sun;Qian [3]Yu;Yuan [5]Yuan;Haodong [4]Lin;Meifang [2]Zhu;Runhui [1,5]Liu 高影响力作者 机构地区：[1]State Key Laboratory of Bioreactor Engineering,College of Chemistry,Chemical Engineering and Materials Science,East China University of Science and Technology,Shanghai,200237,China;[2]State Key Laboratory for Modification of Chemical Fibers and Polymer Materials,College of Materials Science and Engineering,Donghua University,Shanghai,201620,China;[3]Jiangsu Key Laboratory of Advanced Functional Polymers Design and Application,Soochow University,Suzhou,215123,China;[4]Department of Orthopedic Surgery,Shanghai General Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai,200080,China;[5]Key Laboratory for Ultrafine Materials of Ministry of Education,Frontiers Science Center for Materiobiology and Dynamic Chemistry,Research Center for Biomedical Materials of Ministry of Education,School of Materials Science and Engineering,East China University of Science and Technology,Shanghai,200237,China高影响力机构 出　　处：《Bioactive Materials》索引2021年第6卷第12期,共11页高影响力期刊 基　　金：This research was supported by the National Natural Science Foundation of China(No.22075078,21774031);the National Key Research and Development Program of China(2016YFC1100401);Program of Shanghai Academic/Technology Research Leader(20XD1421400);State Key Laboratory for Modification of Chemical Fibers and Polymer Materials,Donghua University,the Natural Science Foundation of Jiangsu Province(BK20180093);the Natural Science Foundation of Shanghai(18ZR1410300);Research program of State Key Laboratory of Bioreactor Engineering,the Fundamental Research Funds for the Central Universities(22221818014);The authors also thank Research Center of Analysis and Test of East China University of Science and Technology for the help on the characterization. 摘　　要：It is an urgent need to tackle drug-resistance microbial infections that are associated with implantable biomedical devices.Host defense peptide-mimicking polymers have been actively explored in recent years to fight against drug-resistant microbes.Our recent report on lithium hexamethyldisilazide-initiated superfast polymerization on amino acid N-carboxyanhydrides enables the quick synthesis of host defense peptide-mimicking peptide polymers.Here we reported a facile and cost-effective thermoplastic polyurethane(TPU)surface modification of peptide polymer(DLL:BLG=90:10)using plasma surface activation and substitution reaction between thiol and bromide groups.The peptide polymer-modified TPU surfaces exhibited board-spectrum antibacterial property as well as effective contact-killing ability in vitro.Furthermore,the peptide polymer-modified TPU surfaces showed excellent biocompatibility,displaying no hemolysis and cytotoxicity.In vivo study using methicillin-resistant Staphylococcus aureus(MRSA)for subcutaneous implantation infectious model showed that peptide polymer-modified TPU surfaces revealed obvious suppression of infection and great histocompatibility,compared to bare TPU surfaces.We further explored the antimicrobial mechanism of the peptide polymer-modified TPU surfaces,which revealed a surface contact-killing mechanism by disrupting the bacterial membrane.These results demonstrated great potential of the peptide-modified TPU surfaces for practical application to combat bacterial infections that are associated with implantable materials and devices. 关 键 词：Peptide polymer Host defense peptide Antimicrobial surface MRSA Subcutaneous infection
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