High-efficiency plastome base editing in rice with TAL cytosine deaminase

查看全文 作　　者：Riqing [1]Li;Si Nian [1]Cha;Bo [1]Liu;Hua [1]Liu;Xianran [2]Li;Bing [1,3]Yang

机构地区：[1]Division of Plant Sciences,Bond Life Sciences Center,University of Missouri,Columbia,MO 65211,USA;[2]USDA-ARS,Wheat Health,Genetics and Quality Research Unit,Pullman,WA 99164,USA;[3]Donald Danforth Plant Science Center,St.Louis,MO 63132,USA

出　　处：《Molecular Plant》索引2021年第14卷第9期,共3页

摘　　要：Dear Editor,Genome editing has been widely applied in nuclei but not so in organelles such as the mitochondria and chloroplasts.The challenge for organelle genome editing is the limited accessibility of editing reagents to the compartments of organelles(Zhu et al.,2020).Recently,fusion proteins of cytidine deaminase domain(DddAtox)and transcription activator-like effectors(TALEs)have been developed for DNA base editing in mitochondria of human cells and mice(Mok et al.,2020;Lee et al.,2021). 关键词：BASE EDITING ORGANELLE

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High-efficiency plastome base editing in rice with TAL cytosine deaminase

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