Fatty acid metabolism and acyl-CoA synthetases in the liver-gut axis

查看全文 作　　者：Yunxia [1]Ma;Miljana [1]Nenkov;Yuan [1]Chen;Adrian T [2]Press;Elke [3]Kaemmerer;Nikolaus [1]Gassler

机构地区：[1]Section Pathology,Institute of Forensic Medicine,Jena University Hospital,Friedrich Schiller University Jena,Jena 07747,Germany;[2]Department of Anesthesiology and Intensive Care Medicine and Center for Sepsis Control and Care,Jena University Hospital,Friedrich Schiller University Jena,Jena 07747,Germany;[3]Department of Pediatrics,Jena University Hospital,Friedrich Schiller University Jena,Jena 07747,Germany

出　　处：《World Journal of Hepatology》索引2021年第13卷第11期,共22页

基　　金：Supported by the Interdisziplinäres Zentrum für Klinische Forschung(IZKF-MSP-06)of University Hospital Jena. 摘　　要：Fatty acids are energy substrates and cell components which participate in regulating signal transduction,transcription factor activity and secretion of bioactive lipid mediators.The acyl-CoA synthetases(ACSs)family containing 26 family members exhibits tissue-specific distribution,distinct fatty acid substrate preferences and diverse biological functions.Increasing evidence indicates that dysregulation of fatty acid metabolism in the liver-gut axis,designated as the bidirectional relationship between the gut,microbiome and liver,is closely associated with a range of human diseases including metabolic disorders,inflammatory disease and carcinoma in the gastrointestinal tract and liver.In this review,we depict the role of ACSs in fatty acid metabolism,possible molecular mechanisms through which they exert functions,and their involvement in hepatocellular and colorectal carcinoma,with particular attention paid to long-chain fatty acids and small-chain fatty acids.Additionally,the liver-gut communication and the liver and gut intersection with the microbiome as well as diseases related to microbiota imbalance in the liver-gut axis are addressed.Moreover,the development of potentially therapeutic small molecules,proteins and compounds targeting ACSs in cancer treatment is summarized. 关键词：Long-chain fatty acids Short-chain fatty acids Acyl-CoA synthetases MICROBIOTA Liver-gut axis

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Fatty acid metabolism and acyl-CoA synthetases in the liver-gut axis

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