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Sustainability of SARS-CoV-2 Induced Humoral Immune Responses in COVID-19 Patients from Hospitalization to Convalescence Over Six Months

查看全文 作　　者：Yang [1,6]Zheng;Qing [2]Zhang;Ashaq [3,9]Ali;Ke [7]Li;Nan [1,9]Shao;Xiaoli [2]Zhou;Zhiqin [2]Ye;Xiaomin [2]Chen;Shanshan [3]Cao;Jing [3,6]Cui;Juan [3]Zhou;Dianbing [1]Wang;Baidong [1]Hou;Min [1]Li;Mengmeng [1]Cui;Lihua [2]Deng;Xinyi [2]Sun;Qian [2]Zhang;Qinfang [7]Yang;Yong [2]li;Hui [5]Wang;Yake [8]Lei;Bo [8]Yu;Yegang [2]Cheng;Xiaolin [4]Tong;Dong [3,9]Men;Xian-En [1,9]Zhang 高影响力作者 机构地区：[1]National Laboratory of Biomacromolecules,CAS Center for Excellence in Biomacromolecules,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China;[2]Hubei Provincial Hospital of Traditional Chinese Medicine,Wuhan 430074,China;[3]State Key Laboratory of Virology,Wuhan Institute of Virology,Chinese Academy of Sciences,Wuhan 430071,China;[4]Guang’an Men Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China;[5]Health Bureau of Wuchang District,Wuhan 430070,China;[6]Hubei University,Wuhan 430074,China;[7]Shenzhen Mindray Bio-Medical Electronics Co.,Ltd,Shenzhen 518057,China;[8]Hubei Provincial Center for Disease Control&Prevention,Wuhan 430079,China;[9]University of Chinese Academy of Sciences,Beijing 100049,China高影响力机构 出　　处：《Virologica Sinica》索引2021年第36卷第5期,共10页高影响力期刊 基　　金：supported by the National Key Research and Development Program of China(Grant No.2020YFC0861100 and 2020YFC0000);the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDB29050100);the Key Technology Development Program of Shenzhen(Grant No.JSGG20200225153042494);the Youth Innovation Promotion Association of CAS(Grant No.2014308);the Interdisciplinary Innovation Team of CAS。 摘　　要：Understanding the persistence of antibody in convalescent COVID-19 patients may help to answer the current major concerns such as the risk of reinfection,the protection period of vaccination and the possibility of building an active herd immunity.This retrospective cohort study included 172 COVID-19 patients who were hospitalized in Wuhan.A total of404 serum samples were obtained over six months from hospitalization to convalescence.Antibodies in the specimens were quantitatively analyzed by the capture chemiluminescence immunoassays(CLIA).All patients were positive for the anti-SARS-Co V-2 Ig M/Ig G at the onset of COVID-19 symptoms,and the Ig G antibody persisted in all the patients during the convalescence.However,only approximately 25%of patients can detect the Ig M antibodies,Ig M against N protein(NIg M)and receptor binding domain of S protein(RBD-Ig M)at the 27 th week.The titers of Ig M,N-Ig M and RBD-Ig M reduced to 16.7%,17.6%and 15.2%of their peak values respectively.In contrast,the titers of Ig G,N-Ig G and RBD-Ig G peaked at 4–5 th week and reduced to 85.9%,62.6%and 87.2%of their peak values respectively at the end of observation.Dynamic behavior of antibodies and their correlation in age,gender and severity groups were investigated.In general,the COVID-19 antibody was sustained at high levels for over six months in most of the convalescent patients.Only a few patients with antibody reducing to an undetectable level which needs further attention.The humoral immune response against SARS-Co V-2 infection in COVID-19 patients exhibits a typical dynamic of acquired immunity. 关 键 词：Coronavirus disease 2019(COVID-19) Humoral Responses SUSTAINABILITY Convalescent
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