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Differentiation of Hepatocellular Carcinoma from Hepatic Hemangioma and Focal Nodular Hyperplasia using Computed Tomographic Spectral Imaging

查看全文 作　　者：Weixia [1]Li;Ruokun [1]Li;Xiangtian [2]Zhao;Xiaozhu [3]Lin;Yixing [4]Yu;Jing [1]Zhang;Kemin [1]Chen;Weimin [1]Chai;Fuhua [1]Yan 高影响力作者 机构地区：[1]Department of Radiology,Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai,China;[2]Department of Radiology,Guangdong General Hospital,Guangdong Academy of Medical Sciences,Guangzhou,Guangdong,China;[3]Department of Nuclear Medicine,Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai,China;[4]Department of Radiology,The First Affiliated Hospital of Soochow University,Suzhou,Jiangsu,China高影响力机构 出　　处：《Journal of Clinical and Translational Hepatology》索引2021年第9卷第3期,共9页高影响力期刊 基　　金：This work was supported by the National Natural Science Foundation of China(Grant number 81401406);the Innovative Research Team of High-Level Local Universities in Shanghai. 摘　　要：Background and Aims:Hepatocellular carcinoma(HCC)is the most common primary hepatic malignancy.This study was designed to investigate the value of computed tomography(CT)spectral imaging in differentiating HCC from hepatic hemangioma(HH)and focal nodular hyperplasia(FNH).Methods:This was a retrospective study of 51 patients who underwent spectral multiple-phase CT at 40–140 keV during the arterial phase(AP)and portal venous phase(PP).Slopes of the spectral curves,iodine density,water density derived from iodine-and water-based material decomposition images,iodine uptake ratio(IUR),normalized iodine concentration,and the ratio of iodine concentration in liver lesions between AP and PP were measured or calculated.Results:As energy level decreased,the CT values of HCC(n=31),HH(n=17),and FNH(n=7)increased in both AP and PP.There were significant differences in IUR in the AP,IUR in the PP,normalized iodine concentration in the AP,slope in the AP,and slope in the PP among HCC,HH,and FNH.The CT values in AP,IUR in the AP and PP,normalized iodine concentration in the AP,slope in the AP and PP had high sensitivity and specificity in differentiating HH and HCC from FNH.Quantitative CT spectral data had higher sensitivity and specificity than conventional qualitative CT image analysis during the combined phases.Conclusions:Mean CT values at low energy(40–90 keV)and quantitative analysis of CT spectral data(IUR in the AP)could be helpful in the differentiation of HCC,HH,and FNH. 关 键 词：Hepatocellular carcinoma Hepatic hemangioma Focal nodular hyperplasia Computed tomography spectral imaging Spectral curve
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