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Comparison of hepatic gene expression profiles between three mouse models of Nonalcoholic Fatty Liver Disease

查看全文 作　　者：Liping [1]Xiang;Yang [1]Jiao;Yiling [1,2]Qian;Yao [3]Li;Fei [1]Mao;Yan [1]Lu 高影响力作者 机构地区：[1]Department of Endocrinology and Metabolism,Zhongshan Hospital,Fudan University,Shanghai 200032,PR China;[2]Department of Endocrinology and Metabolism,Minhang Branch,Zhongshan Hospital,Central Hospital of Minhang District,Shanghai Minhang Hospital,Fudan University,Shanghai 200032,PR China;[3]Department of Laboratory Animal Science,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,PR China高影响力机构 出　　处：《Genes & Diseases》索引2022年第9卷第1期,共15页高影响力期刊 基　　金：This work was supported by National Key Research and Development Program of China(No.2018YFA0800402);National Natural Science Foundation of China(No.81974119);Shanghai Science Foundation(No.18ZR1437800);Shanghai Jiaotong University Foundation(No.shklab202012). 摘　　要：Non-alcoholic fatty liver disease (NAFLD) has become the most common chronic liver disorder worldwide. Murine models of NAFLD have been widely used to explore its pathogenesis. In this study, we performed a systematic evaluation of hepatic genome-wide mRNA expression by RNA-Sequencing using three mouse models of NAFLD: leptin receptor deficient db/db mice, high-fat high-sugar diet (HSHF)-induced obese mice, and dexamethasone (DEX)-induced NAFLD mice. As a result, we found both distinct and common pathways in the regulation of lipid metabolism from transcriptomes of three mouse models. Moreover, only a total of 12 differentially expressed genes (DEGs) were commonly detected among all three mouse groups, indicating very little overlap among all three models. Therefore, our results suggest that NAFLD is a heterogeneous disease with highly variable molecular mechanisms. 关 键 词：DEGs Murine models NAFLD Pathway analysis TRANSCRIPTOME
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