Is more evidence needed for thrombectomy in basilar artery occlusion? The BASICS and BEST meta- analytical approaches

查看全文 作　　者：Davi J Fontoura [1,2]Solla;Felipe Coelho [3]Argolo;Karol P [4]Budohoski;Angelos G [2,4]Kolias;JoséGuilherme M P [5]Caldas;Jamary Oliveira-[6]Filho 机构地区：[1]Division of Neurosurgery,Department of Neurology,University of Sao Paulo,Sao Paulo,Brazil;[2]NIHR Global Health Research Group on Neurotrauma,Cambridge University,Cambridge,UK;[3]Machine Learning for Mental Health Lab,King's College London,London,UK;[4]Division of Neurosurgery,Department of Clinical Neurosciences,Addenbrooke's Hospital,Cambridge University,Cambridge,UK;[5]Radiology,University of Sao Paulo,Sao Paulo,Brazil;[6]Postgraduate Program in Health Sciences,Federal University of Bahia,Salvador,Bahia,Brazil 出　　处：《Stroke & Vascular Neurology》索引2021年第6卷第4期,共5页 摘　　要：INTRODUCTION The benefit of mechanical thrombectomy for stroke associated with anterior circulation large vessel occlusion(LVO)is well established and among the most effective treatments in medicine.1 Stroke associated with basilar artery occlusion(BAO)was not included in the seminal thrombectomy randomised clin-ical trials(RCTs).BAO accounts for 1%of the ischaemic strokes and 5%-10%of the LVO,but 70%-80%of BAO victims evolve to death or full dependence.23 The terminal nature of the brainstem and thalamic circulations may predispose to such dismal outcomes.Only two RCT designed to assess the efficacy of early(<6-8 hours since symptoms onset)thrombectomy for BAO treatment,the BEST and BASICS trials.24 Given the prior evidence for thrombectomy benefit for anterior circu-lation stroke is well settled;BAO stroke shares a similar physiopathology with very poor prog-nosis. 关 键 词：throm OCCLUSION BASILAR