One step synthesis of efficient red emissive carbon dots and their bovine serum albumin composites with enhanced multi-photon fluorescence for in vivo bioimaging

查看全文 作　　者：Huiqi [1]Zhang;Gang [1]Wang;Zhiming [2,3]Zhang;Josh Haipeng [3,4]Lei;Tzu-Ming [2,3]Liu;Guichuan [1]Xing;Chu-Xia [3,4]Deng;Zikang [1]Tang;Songnan [1]Qu

机构地区：[1]Joint Key Laboratory of the Ministry of Education,Institute of Applied Physics and Materials Engineering,University of Macao,Macao 999078,China;[2]Institute of Translational Medicine,Faculty of Health Sciences,University of Macao,Macao 999078,China;[3]MoE Frontiers Science Center for Precision Oncology,University of Macao,Macao 999078,China;[4]Cancer Center,Faculty of Health Sciences,University of Macao,Macao 999078,China

出　　处：《Light(Science & Applications)》索引2022年第11卷第5期,共14页

基　　金：supported by the Natural Science Foundation of China(No.61922091);the Science and Technology Development Fund of Macao SAR(0040/2019/A1,0073/2019/AMJ,0011/2019/AKP,0128/2020/A3,0131/2020/A3 and 0120/2020/A3);Fund from the University of Macao(SRG2019-00163-IAPME);Research and Development Grant for Chair Professor Fund from the University of Macao(CPG2020-00026-IAPME);Research Grant(MYRG2019-00103-IAPME,MYRG2020-00164-IAPME)from the University of Macao. 摘　　要：Efficient red emissive carbon dots(CDs)in aqueous solutions are very scarce for high performance bioimaging applications.In this work,we report a one-step solvothermal treatment to synthesize pure red emissive CDs(FA-CDs)from citric acid and urea in formic acid without complicated purification procedures.Photoluminescence quantum yield(PLQY)of 43.4%was observed in their dimethyl sulfoxide solutions.High PLQY up to 21.9%in aqueous solutions was achieved in their bovine serum albumin(BSA)composites(FA-CDs@BSA)with significantly enhanced multiphoton fluorescence.The strong surface electron-withdrawing structure of FA-CDs caused by the high content of C=O groups contributes for their pure red emission.Owing to the significantly enhanced single and multi-photon red fluorescence and enlarged particle sizes after composing with BSA,in vivo tumor imaging and two-photon fluorescence imaging of blood vessels in mouse ear have been realized via intravenous injection of FA-CDs@BSA aqueous solutions. 关键词：PHOTON PURE synthesis

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One step synthesis of efficient red emissive carbon dots and their bovine serum albumin composites with enhanced multi-photon fluorescence for in vivo bioimaging

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